DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SPOP_SBC_1

Location: 1706:1710

E3 ligase: SPOP

DEGRON score: 0.8956

ASA_SCORE: 85.9

COIL: 0.9194

CONS_SCORE: 0.1918

DSS_SCORE: 0.6967

HELIX: 0.0266

FCONS_SCORE: 1.0306

RIG_SCORE: 0.605

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1700A	TCGA-56-A5DS	LUSC	TCGA	ATSTS	DEG_SPOP_SBC_1	0.1667
p.S1700A	DO45494	LUSC	ICGC	ATSTS	DEG_SPOP_SBC_1	0.1667
p.S1710F	TCGA-AC-A23H	BRCA	TCGA	ATSTS	DEG_SPOP_SBC_1	0.7982
p.S1710F	TCGA-BS-A0UF	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	0.7982
p.S1710F	DO2401	BRCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.7982
p.S1710F	DO41488	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	0.7982
p.T1707I	TCGA-AJ-A3EL	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	0.5966
p.T1707I	DO41542	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	0.5966
p.S1696T	TCGA-DD-AAC8	LIHC	TCGA	ATSTS	DEG_SPOP_SBC_1	0.0556
p.S1696T	DO52193	LIHC	ICGC	ATSTS	DEG_SPOP_SBC_1	0.0556
p.E1705K	TCGA-FW-A3R5	SKCM	TCGA	ATSTS	DEG_SPOP_SBC_1	0.3056
p.E1705K	DO37406	SKCM	ICGC	ATSTS	DEG_SPOP_SBC_1	0.3056
p.S1708P	DO224616	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.6752
p.S1708P	DO222746	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.6752
p.S1708P	DO222835	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.6752
p.A1706V	DO224620	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.5825
p.A1706V	DO222746	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.5825
p.A1706V	DO222835	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.5825
p.H1697Q	DO224739	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.0833
p.A1704P	DO222746	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.2778
p.A1704P	DO222835	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.2778
p.A1704P	DO229016	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.2778
p.A1704P	DO52338	LUSC	ICGC	ATSTS	DEG_SPOP_SBC_1	0.2778
p.H1702Q	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	0.2222
p.H1702Q	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	0.2222
p.H1702Q	SIDM01613	Colorectal Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	0.2222
p.H1702Q	HCC-78	lung	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.2222
p.H1702Q	NCI-H2023	lung	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.2222
p.S1699Y	SIDM00572	Gastric Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	0.1389
p.S1699Y	NUGC-3	stomach	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.1389
p.S1710C	SIDM01146	Gastric Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	0.7541
p.S1710C	NCI-SNU-1	stomach	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.7541
p.N1713T	BE2-M17	autonomic_ganglia	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43167	Zinc finger and BTB domain-containing protein 24	DEG_SPOP_SBC_1	661:665	ATSTS	SPOP	0.8818	More...
O75061	Putative tyrosine-protein phosphatase auxilin	DEG_SPOP_SBC_1	564:568	ATSTS	SPOP	0.9989	More...
P51826	AF4/FMR2 family member 3	DEG_SPOP_SBC_1	846:850	ATSTS	SPOP	0.9984	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2250:2254	ATSTS	SPOP	0.9964	More...
Q13164	Mitogen-activated protein kinase 7	DEG_SPOP_SBC_1	658:662	ATSTS	SPOP	0.6439	More...
Q3T8J9	GON-4-like protein	DEG_SPOP_SBC_1	2218:2222	ATSTS	SPOP	0.6171	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1706:1710	ATSTS	SPOP	0.8956	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1170:1174	ATSTS	SPOP	0.9971	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	238:242	ATSTS	SPOP	0.9886	More...
Q96IZ7	Serine/Arginine-related protein 53	DEG_SPOP_SBC_1	263:267	ATSTS	SPOP	0.9754	More...
Q9NQC1	E3 ubiquitin-protein ligase Jade-2	DEG_SPOP_SBC_1	22:26	ATSTS	SPOP	0.9861	More...
Q9NQG7	Hermansky-Pudlak syndrome 4 protein	DEG_SPOP_SBC_1	2:6	ATSTS	SPOP	0.7449	More...
Q9NR71	Neutral ceramidase	DEG_SPOP_SBC_1	701:705	ATSTS	SPOP	0.7751	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	840:844	ATSTS	SPOP	0.7206	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	1908:1912	ATSTS	SPOP	0.702	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	2690:2694	ATSTS	SPOP	0.9814	More...
Q9Y5P4	Ceramide transfer protein	DEG_SPOP_SBC_1	145:149	ATSTS	SPOP	0.9864	More...
Q96T17	MAP7 domain-containing protein 2	DEG_SPOP_SBC_1	229:233	ATSTS	SPOP	0.9487	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	26:30	ATSTS	SPOP	0.881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSTS

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of ATSTS