DegronMD - Q5VZ18(SHE)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N122H	TCGA-2W-A8YY	CESC	TCGA	SRDSLQGLI	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.0556
p.N122H	DO223732	CESC	ICGC	SRDSLQGLI	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.0556
p.R120H	TCGA-61-2104	OV	TCGA	SRDSLQGLI	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1111
p.R120H	DO31849	OV	ICGC	SRDSLQGLI	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1111
p.N122D	TCGA-91-6836	LUAD	TCGA	SRDSLQGLI	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.0556
p.N122D	DO23854	LUAD	ICGC	SRDSLQGLI	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.0556
p.S166I	TCGA-AP-A059	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.8453
p.S166I	DO41361	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.8453
p.A175T	TCGA-B5-A1MR	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.0833
p.A175T	DO41758	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.0833
p.S107N	TCGA-BR-A453	STAD	TCGA	SRDSLQGLI	DEG_APCC_DBOX_1	104:112	Mutation altering degron motif	0.5958
p.S107N	DO47919	STAD	ICGC	SRDSLQGLI	DEG_APCC_DBOX_1	104:112	Mutation altering degron motif	0.5958
p.Q153E	TCGA-FD-A6TC	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.0833
p.Q153E	DO49755	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.0833
p.R105C	TCGA-L5-A4OI	ESCA	TCGA	SRDSLQGLI	DEG_APCC_DBOX_1	104:112	Mutation altering degron motif	0.8301
p.N160K	DO229024	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2778
p.I112F	DO51153	PRAD	ICGC	SRDSLQGLI	DEG_APCC_DBOX_1	104:112	Mutation altering degron motif	0.6304
p.S10P	DO229240	THCA	ICGC	PTPGAS	DEG_SCF_FBW7_1	5:10	Mutation altering degron motif	0.6752
p.S171Y	SIDM00082	Melanoma	GDSC	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.S171Y	ACH-001190	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.S171Y	SK-MEL-2	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.Y161C	SIDM00223	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.Y161C	ACH-002144	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.Y161C	IST-SL1	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.S163G	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.5882
p.S163G	ACH-000912	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.5882
p.T6I	ACH-000943	Colon/Colorectal Cancer	CCLE	PTPGAS	DEG_SCF_FBW7_1	5:10	Mutation altering degron motif	0.7078
p.A116T	ACH-000985	Colon/Colorectal Cancer	CCLE	SRDSLQGLI	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHE

UniProt ID: Q5VZ18

Entrez ID: 126669

Protein name: SH2 domain-containing adapter protein E

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SHE in