DegronMD

Uniprot ID: Q5VZ18

Source protein: SH2 domain-containing adapter protein E

Source gene: SHE

Class: DEG_APCC_DBOX_1

Location: 104:112

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9082

ASA_SCORE: 63.7556

COIL: 0.2719

CONS_SCORE: 0.4767

DSS_SCORE: 0.6215

HELIX: 0.7063

FCONS_SCORE: 1.0781

RIG_SCORE: 0.7186

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N122H	TCGA-2W-A8YY	CESC	TCGA	SRDSLQGLI	DEG_APCC_DBOX_1	0.0556
p.N122H	DO223732	CESC	ICGC	SRDSLQGLI	DEG_APCC_DBOX_1	0.0556
p.R120H	TCGA-61-2104	OV	TCGA	SRDSLQGLI	DEG_APCC_DBOX_1	0.1111
p.R120H	DO31849	OV	ICGC	SRDSLQGLI	DEG_APCC_DBOX_1	0.1111
p.N122D	TCGA-91-6836	LUAD	TCGA	SRDSLQGLI	DEG_APCC_DBOX_1	0.0556
p.N122D	DO23854	LUAD	ICGC	SRDSLQGLI	DEG_APCC_DBOX_1	0.0556
p.S107N	TCGA-BR-A453	STAD	TCGA	SRDSLQGLI	DEG_APCC_DBOX_1	0.5958
p.S107N	DO47919	STAD	ICGC	SRDSLQGLI	DEG_APCC_DBOX_1	0.5958
p.R105C	TCGA-L5-A4OI	ESCA	TCGA	SRDSLQGLI	DEG_APCC_DBOX_1	0.8301
p.I112F	DO51153	PRAD	ICGC	SRDSLQGLI	DEG_APCC_DBOX_1	0.6304
p.A116T	ACH-000985	Colon/Colorectal Cancer	CCLE	SRDSLQGLI	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZ18	SH2 domain-containing adapter protein E	DEG_APCC_DBOX_1	104:112	SRDSLQGLI	APC,CDC20,FZR1	0.9082	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons