DegronMD

Uniprot ID: Q8NAG6

Source protein: Ankyrin repeat and LEM domain-containing protein 1

Source gene: ANKLE1

Class: DEG_APCC_DBOX_1

Location: 247:255

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5994

ASA_SCORE: 76.0889

COIL: 0.5676

CONS_SCORE: 0.2516

DSS_SCORE: 0.5319

HELIX: 0.0769

FCONS_SCORE: 0.8057

RIG_SCORE: 0.7073

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A257V	TCGA-AP-A051	UCEC	TCGA	TRQGLLHVV	DEG_APCC_DBOX_1	0.2778
p.A257V	DO42673	UCEC	ICGC	TRQGLLHVV	DEG_APCC_DBOX_1	0.2778
p.A241T	TCGA-AX-A0J1	UCEC	TCGA	TRQGLLHVV	DEG_APCC_DBOX_1	0.1667
p.A241T	DO41199	UCEC	ICGC	TRQGLLHVV	DEG_APCC_DBOX_1	0.1667
p.V261L	TCGA-D7-A747	STAD	TCGA	TRQGLLHVV	DEG_APCC_DBOX_1	0.1667
p.V261L	DO51735	STAD	ICGC	TRQGLLHVV	DEG_APCC_DBOX_1	0.1667
p.P238L	TCGA-FR-A3YO	SKCM	TCGA	TRQGLLHVV	DEG_APCC_DBOX_1	0.0833
p.P238L	DO37419	SKCM	ICGC	TRQGLLHVV	DEG_APCC_DBOX_1	0.0833
p.P238A	TCGA-GU-AATQ	BLCA	TCGA	TRQGLLHVV	DEG_APCC_DBOX_1	0.0833
p.P238A	DO51896	BLCA	ICGC	TRQGLLHVV	DEG_APCC_DBOX_1	0.0833
p.G250E	DO233240	GACA	ICGC	TRQGLLHVV	DEG_APCC_DBOX_1	0.6087
p.G243R	SIDM01188	Pancreatic Carcinoma	GDSC	TRQGLLHVV	DEG_APCC_DBOX_1	0.2222
p.G243R	SU8686	pancreas	COSMIC	TRQGLLHVV	DEG_APCC_DBOX_1	0.2222
p.E239K	SIDM00207	Glioblastoma	GDSC	TRQGLLHVV	DEG_APCC_DBOX_1	0.1111
p.E239K	D-542MG	central_nervous_system	COSMIC	TRQGLLHVV	DEG_APCC_DBOX_1	0.1111
p.L251F	ACH-000177	Prostate Cancer	CCLE	TRQGLLHVV	DEG_APCC_DBOX_1	0.6981
p.H256R	ACH-000391	Bone Cancer	CCLE	TRQGLLHVV	DEG_APCC_DBOX_1	0.3056
p.H256N	ACH-000947	Ovarian Cancer	CCLE	TRQGLLHVV	DEG_APCC_DBOX_1	0.3056
p.Q265R	ACH-000988	Endometrial/Uterine Cancer	CCLE	TRQGLLHVV	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NAG6	Ankyrin repeat and LEM domain-containing protein 1	DEG_APCC_DBOX_1	247:255	TRQGLLHVV	APC,CDC20,FZR1	0.5994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons