DegronMD

Uniprot ID: Q86TM6

Source protein: E3 ubiquitin-protein ligase synoviolin

Source gene: SYVN1

Class: DEG_APCC_DBOX_1

Location: 604:612

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7755

ASA_SCORE: 112.7

COIL: 0.2608

CONS_SCORE: 0.2663

DSS_SCORE: 0.7075

HELIX: 0.7433

FCONS_SCORE: 1.1267

RIG_SCORE: 0.7252

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R607C	TCGA-PG-A5BC	UCEC	TCGA	RRRRLQKLE	DEG_APCC_DBOX_1	0.719
p.R607C	DO48171	UCEC	ICGC	RRRRLQKLE	DEG_APCC_DBOX_1	0.719
p.L607P	DO233732	GACA	ICGC	RRRRLQKLE	DEG_APCC_DBOX_1	0.7582
p.R606S	DO229019	LICA	ICGC	RRRRLQKLE	DEG_APCC_DBOX_1	0.6316
p.R605G	DO23496	LINC	ICGC	RRRRLQKLE	DEG_APCC_DBOX_1	0.7568
p.R605G	DO45053	LINC	ICGC	RRRRLQKLE	DEG_APCC_DBOX_1	0.7568
p.L611M	DO23330	LINC	ICGC	RRRRLQKLE	DEG_APCC_DBOX_1	0.5999
p.R606H	SIDM01943	Colorectal Carcinoma	GDSC	RRRRLQKLE	DEG_APCC_DBOX_1	0.7133
p.P614H	SIDM00120	Prostate Carcinoma	GDSC	RRRRLQKLE	DEG_APCC_DBOX_1	0.2778
p.P614H	ACH-000979	Prostate Cancer	CCLE	RRRRLQKLE	DEG_APCC_DBOX_1	0.2778
p.P614H	DU-145	prostate	COSMIC	RRRRLQKLE	DEG_APCC_DBOX_1	0.2778
p.L611P	SIDM00487	Colorectal Carcinoma	GDSC	RRRRLQKLE	DEG_APCC_DBOX_1	0.7582
p.L611P	ACH-000963	Colon/Colorectal Cancer	CCLE	RRRRLQKLE	DEG_APCC_DBOX_1	0.7582
p.L611P	CCK-81	large_intestine	COSMIC	RRRRLQKLE	DEG_APCC_DBOX_1	0.7582
p.A616T	SIDM00954	Breast Carcinoma	GDSC	RRRRLQKLE	DEG_APCC_DBOX_1	0.2222
p.A616T	COLO-824	breast	COSMIC	RRRRLQKLE	DEG_APCC_DBOX_1	0.2222
p.L610P	CCK-81	large_intestine	COSMIC	RRRRLQKLE	DEG_APCC_DBOX_1	0.7582
p.P613H	DU-145	prostate	COSMIC	RRRRLQKLE	DEG_APCC_DBOX_1	0.75
p.A615T	COLO-824	breast	COSMIC	RRRRLQKLE	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_APCC_DBOX_1	604:612	RRRRLQKLE	APC,CDC20,FZR1	0.7755	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons