DegronMD - O43516(WIPF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P250L	TCGA-39-5037	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.P250L	TCGA-JY-A6FG	ESCA	TCGA	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.P250L	DO27429	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.T297A	TCGA-51-4081	LUSC	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.7139
p.T297A	DO26544	LUSC	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.7139
p.G231E	TCGA-90-A4ED	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1111
p.G231E	DO45482	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1111
p.S244L	TCGA-97-7547	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation blocking phosphorylation signal	0.75
p.S244L	DO234190	ESAD	ICGC	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation blocking phosphorylation signal	0.75
p.S244L	DO23594	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation blocking phosphorylation signal	0.75
p.P298L	TCGA-AA-3864	COAD	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.7582
p.P298L	DO8490	COAD	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.7582
p.R236H	TCGA-AG-3725	READ	TCGA	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.R236H	DO36745	READ	ICGC	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.P292H	TCGA-AP-A051	UCEC	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.2778
p.P292H	DO42673	UCEC	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.2778
p.P309L	TCGA-BH-A0DT	BRCA	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1111
p.P309L	DO2503	BRCA	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1111
p.P295H	TCGA-BP-5009	KIRC	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.6583
p.P295H	DO18512	KIRC	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.6583
p.D443H	TCGA-BT-A42E	BLCA	TCGA	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1389
p.D443H	DO44030	BLCA	ICGC	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1389
p.G426R	TCGA-CR-7386	HNSC	TCGA	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1667
p.G426R	DO14348	HNSC	ICGC	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1667
p.N289S	TCGA-D1-A103	UCEC	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1944
p.N289S	DO42312	UCEC	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1944
p.R299L	TCGA-D3-A3CE	SKCM	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.7316
p.R299L	DO37405	SKCM	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.7316
p.N439H	TCGA-E6-A1LX	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.25
p.N439H	DO41020	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.25
p.G317W	TCGA-EE-A3AA	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.1944
p.G317W	DO37571	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.1944
p.P293L	TCGA-ET-A3BQ	THCA	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.3056
p.P293L	DO40417	THCA	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.3056
p.D443N	TCGA-F5-6814	READ	TCGA	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1389
p.D443N	DO36556	READ	ICGC	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1389
p.P286H	TCGA-GN-A262	SKCM	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1111
p.P286H	DO37515	SKCM	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1111
p.P429S	TCGA-HU-A4G6	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.25
p.P429S	DO47747	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.25
p.P312A	TCGA-NC-A5HN	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.0556
p.P312A	DO52025	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.0556
p.A306V	TCGA-XF-A9SY	BLCA	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1944
p.A306V	DO51918	BLCA	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1944
p.E330K	DO222765	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.2222
p.G232V	DO234161	ESAD	ICGC	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.R438I	DO222654	ESCA	ICGC	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.2778
p.P430L	DO228189	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.2778
p.S326R	DO228974	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	322:326	Mutation altering degron motif	0.7427
p.D329E	DO229034	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.25
p.N290K	DO229038	LICA	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.2222
p.P239S	DO222743	MELA	ICGC	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.6752
p.P284S	DO222887	MELA	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.0556
p.D443Y	DO229077	PRAD	ICGC	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1389
p.R422W	DO229259	THCA	ICGC	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.0556
p.G233S	SIDM00884	Breast Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1667
p.G233S	ACH-000699	Breast Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1667
p.G233S	HCC1395	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1667
p.S424G	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1111
p.S424G	ACH-000937	Leukemia	CCLE	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1111
p.S424G	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1111
p.P335Q	ACH-000659	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.0833
p.A427V	ACH-001997	Bile Duct Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WIPF1

UniProt ID: O43516

Entrez ID: 7456

Protein name: WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WIPF1 in