DegronMD

Uniprot ID: O43516

Source protein: WAS/WASL-interacting protein family member 1

Source gene: WIPF1

Class: DEG_SCF_FBW7_1

Location: 294:301

E3 ligase: FBXW7

DEGRON score: 0.9267

ASA_SCORE: 96.6125

COIL: 0.9753

CONS_SCORE: 0.6892

DSS_SCORE: 0.854

HELIX: 0.0128

FCONS_SCORE: 1.0786

RIG_SCORE: 0.4445

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T297A	TCGA-51-4081	LUSC	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	0.7139
p.T297A	DO26544	LUSC	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	0.7139
p.P298L	TCGA-AA-3864	COAD	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	0.7582
p.P298L	DO8490	COAD	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	0.7582
p.P292H	TCGA-AP-A051	UCEC	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	0.2778
p.P292H	DO42673	UCEC	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	0.2778
p.P309L	TCGA-BH-A0DT	BRCA	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	0.1111
p.P309L	DO2503	BRCA	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	0.1111
p.P295H	TCGA-BP-5009	KIRC	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	0.6583
p.P295H	DO18512	KIRC	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	0.6583
p.N289S	TCGA-D1-A103	UCEC	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	0.1944
p.N289S	DO42312	UCEC	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	0.1944
p.R299L	TCGA-D3-A3CE	SKCM	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	0.7316
p.R299L	DO37405	SKCM	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	0.7316
p.P293L	TCGA-ET-A3BQ	THCA	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	0.3056
p.P293L	DO40417	THCA	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	0.3056
p.P286H	TCGA-GN-A262	SKCM	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	0.1111
p.P286H	DO37515	SKCM	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	0.1111
p.A306V	TCGA-XF-A9SY	BLCA	TCGA	VPSTPRPS	DEG_SCF_FBW7_1	0.1944
p.A306V	DO51918	BLCA	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	0.1944
p.N290K	DO229038	LICA	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	0.2222
p.P284S	DO222887	MELA	ICGC	VPSTPRPS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43516	WAS/WASL-interacting protein family member 1	DEG_SCF_FBW7_1	294:301	VPSTPRPS	FBXW7	0.9267	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons