DegronMD

Uniprot ID: Q6P2E9

Source protein: Enhancer of mRNA-decapping protein 4

Source gene: EDC4

Class: DEG_APCC_KENBOX_2

Location: 1081:1085

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8442

ASA_SCORE: 80.7

COIL: 0.049

CONS_SCORE: 0.4033

DSS_SCORE: 0.3376

HELIX: 0.9492

FCONS_SCORE: 1.1029

RIG_SCORE: 0.7748

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1091F	TCGA-YD-A9TA	SKCM	TCGA	MKENI	DEG_APCC_KENBOX_2	0.1667
p.S1091F	DO219503	SKCM	ICGC	MKENI	DEG_APCC_KENBOX_2	0.1667
p.A1071S	DO229018	LICA	ICGC	MKENI	DEG_APCC_KENBOX_2	0.0556
p.A1071T	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	MKENI	DEG_APCC_KENBOX_2	0.0556
p.A1071T	SIDM00449	B-Lymphoblastic Leukemia	GDSC	MKENI	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 5 of 5 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPW5	Cytosolic carboxypeptidase 1	DEG_APCC_KENBOX_2	477:481	MKENI	APC,CDC20,FZR1	0.605	More...
Q6P2E9	Enhancer of mRNA-decapping protein 4	DEG_APCC_KENBOX_2	1081:1085	MKENI	APC,CDC20,FZR1	0.8442	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons