DegronMD - Q9UPW5(AGTPBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T479S	TCGA-12-1088	GBM	TCGA	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation altering degron motif	0.7116
p.T479S	TCGA-23-1032	OV	TCGA	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation altering degron motif	0.7116
p.D489Y	TCGA-AP-A1DV	UCEC	TCGA	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.1111
p.P473S	TCGA-AX-A05Z	UCEC	TCGA	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.2222
p.R467I	TCGA-B5-A1MR	UCEC	TCGA	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.0556
p.R478I	TCGA-BS-A0UF	UCEC	TCGA	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation altering degron motif	0.8102
p.R478I	TCGA-EO-A3B0	UCEC	TCGA	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation altering degron motif	0.8102
p.V483A	TCGA-FI-A2D5	UCEC	TCGA	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.2778
p.V540F	TCGA-NK-A5CR	LUSC	TCGA	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation altering degron motif	0.7068
p.M489I	DO2401	BRCA	ICGC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.1111
p.R548Q	DO222798	COCA	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.1944
p.T531S	DO13701	GBM	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.2222
p.T531S	DO32267	OV	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.2222
p.Q545E	DO44431	HNSC	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.2778
p.M489L	DO231590	LINC	ICGC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.1111
p.V475A	DO48654	SKCM	ICGC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.2778
p.G482D	DO38727	STAD	ICGC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.3056
p.D541Y	DO43186	UCEC	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation altering degron motif	0.7325
p.L546V	DO43755	UCEC	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.25
p.I481V	DO43755	UCEC	ICGC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation altering degron motif	0.5965
p.V535A	DO41331	UCEC	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation altering degron motif	0.6936
p.Y488C	SIDM00198	Ewing's Sarcoma	GDSC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.1389
p.Y488C	EW-16	bone	COSMIC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.1389
p.S544A	SIDM00934	Pancreatic Carcinoma	GDSC	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.3056
p.S544A	CAPAN-1	pancreas	COSMIC	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.3056
p.I468T	SIDM00382	Glioblastoma	GDSC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.0833
p.I468T	SF126	central nervous system	COSMIC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.0833
p.H476Y	SIDM00214	Colorectal Carcinoma	GDSC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.3056
p.H476Y	SNU-407	large intestine	COSMIC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.3056
p.Q471R	ACH-000335	Lung Cancer	CCLE	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.1667
p.Q471R	MSTO-211H	pleura	COSMIC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.1667
p.H484Y	ACH-000493	Liver Cancer	CCLE	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation substituting flanking lysine	0.3611
p.H484Y	SNU-423	liver	COSMIC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation substituting flanking lysine	0.3611
p.C537G	ACH-000987	Skin Cancer	CCLE	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation altering degron motif	0.76
p.C537G	Mewo	skin	COSMIC	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation altering degron motif	0.76
p.V540G	ACH-001616	Lymphoma	CCLE	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation altering degron motif	0.7532
p.A473V	SNU-1040	large intestine	COSMIC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.2222
p.R545K	Hs-578-T	breast	COSMIC	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.2778
p.H536Y	SNU-423	liver	COSMIC	DRITLQNIP	DEG_APCC_DBOX_1	535:543	Mutation altering degron motif	0.7229
p.D470G	NCI-H1417	lung	COSMIC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.1389
p.N483D	CESS	haematopoietic and lymphoid tissue	COSMIC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.2778
p.N471D	CESS	haematopoietic and lymphoid tissue	COSMIC	MKENI	DEG_APCC_KENBOX_2	477:481	Mutation rewiring degron network	0.1667

Kaplan plot for AGTPBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AGTPBP1

UniProt ID: Q9UPW5

Entrez ID: 23287

Protein name: Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1 homolog) (Protein deglutamylase CCP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AGTPBP1 in