DegronMD

Uniprot ID: Q9UPW5

Source protein: Cytosolic carboxypeptidase 1

Source gene: AGTPBP1

Class: DEG_APCC_DBOX_1

Location: 535:543

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6252

ASA_SCORE: 84.2111

COIL: 0.5874

CONS_SCORE: 0.2613

DSS_SCORE: 0.3265

HELIX: 0.3791

FCONS_SCORE: 1.054

RIG_SCORE: 0.8158

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V540F	TCGA-NK-A5CR	LUSC	TCGA	DRITLQNIP	DEG_APCC_DBOX_1	0.7068
p.R548Q	DO222798	COCA	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	0.1944
p.T531S	DO13701	GBM	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	0.2222
p.T531S	DO32267	OV	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	0.2222
p.Q545E	DO44431	HNSC	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	0.2778
p.D541Y	DO43186	UCEC	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	0.7325
p.L546V	DO43755	UCEC	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	0.25
p.V535A	DO41331	UCEC	ICGC	DRITLQNIP	DEG_APCC_DBOX_1	0.6936
p.S544A	SIDM00934	Pancreatic Carcinoma	GDSC	DRITLQNIP	DEG_APCC_DBOX_1	0.3056
p.S544A	CAPAN-1	pancreas	COSMIC	DRITLQNIP	DEG_APCC_DBOX_1	0.3056
p.C537G	ACH-000987	Skin Cancer	CCLE	DRITLQNIP	DEG_APCC_DBOX_1	0.76
p.C537G	Mewo	skin	COSMIC	DRITLQNIP	DEG_APCC_DBOX_1	0.76
p.V540G	ACH-001616	Lymphoma	CCLE	DRITLQNIP	DEG_APCC_DBOX_1	0.7532
p.R545K	Hs-578-T	breast	COSMIC	DRITLQNIP	DEG_APCC_DBOX_1	0.2778
p.H536Y	SNU-423	liver	COSMIC	DRITLQNIP	DEG_APCC_DBOX_1	0.7229

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPW5	Cytosolic carboxypeptidase 1	DEG_APCC_DBOX_1	535:543	DRITLQNIP	APC,CDC20,FZR1	0.6252	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons