DegronMD

Uniprot ID: Q9UPW5

Source protein: Cytosolic carboxypeptidase 1

Source gene: AGTPBP1

Class: DEG_APCC_KENBOX_2

Location: 477:481

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.605

ASA_SCORE: 99.5

COIL: 0.49

CONS_SCORE: 0.2609

DSS_SCORE: 0.5304

HELIX: 0.0342

FCONS_SCORE: 1.0108

RIG_SCORE: 0.754

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T479S	TCGA-12-1088	GBM	TCGA	MKENI	DEG_APCC_KENBOX_2	0.7116
p.T479S	TCGA-23-1032	OV	TCGA	MKENI	DEG_APCC_KENBOX_2	0.7116
p.D489Y	TCGA-AP-A1DV	UCEC	TCGA	MKENI	DEG_APCC_KENBOX_2	0.1111
p.P473S	TCGA-AX-A05Z	UCEC	TCGA	MKENI	DEG_APCC_KENBOX_2	0.2222
p.R467I	TCGA-B5-A1MR	UCEC	TCGA	MKENI	DEG_APCC_KENBOX_2	0.0556
p.R478I	TCGA-BS-A0UF	UCEC	TCGA	MKENI	DEG_APCC_KENBOX_2	0.8102
p.R478I	TCGA-EO-A3B0	UCEC	TCGA	MKENI	DEG_APCC_KENBOX_2	0.8102
p.V483A	TCGA-FI-A2D5	UCEC	TCGA	MKENI	DEG_APCC_KENBOX_2	0.2778
p.M489I	DO2401	BRCA	ICGC	MKENI	DEG_APCC_KENBOX_2	0.1111
p.M489L	DO231590	LINC	ICGC	MKENI	DEG_APCC_KENBOX_2	0.1111
p.V475A	DO48654	SKCM	ICGC	MKENI	DEG_APCC_KENBOX_2	0.2778
p.G482D	DO38727	STAD	ICGC	MKENI	DEG_APCC_KENBOX_2	0.3056
p.I481V	DO43755	UCEC	ICGC	MKENI	DEG_APCC_KENBOX_2	0.5965
p.Y488C	SIDM00198	Ewing's Sarcoma	GDSC	MKENI	DEG_APCC_KENBOX_2	0.1389
p.Y488C	EW-16	bone	COSMIC	MKENI	DEG_APCC_KENBOX_2	0.1389
p.I468T	SIDM00382	Glioblastoma	GDSC	MKENI	DEG_APCC_KENBOX_2	0.0833
p.I468T	SF126	central_nervous_system	COSMIC	MKENI	DEG_APCC_KENBOX_2	0.0833
p.H476Y	SIDM00214	Colorectal Carcinoma	GDSC	MKENI	DEG_APCC_KENBOX_2	0.3056
p.H476Y	SNU-407	large_intestine	COSMIC	MKENI	DEG_APCC_KENBOX_2	0.3056
p.Q471R	ACH-000335	Lung Cancer	CCLE	MKENI	DEG_APCC_KENBOX_2	0.1667
p.Q471R	MSTO-211H	pleura	COSMIC	MKENI	DEG_APCC_KENBOX_2	0.1667
p.H484Y	ACH-000493	Liver Cancer	CCLE	MKENI	DEG_APCC_KENBOX_2	0.3611
p.H484Y	SNU-423	liver	COSMIC	MKENI	DEG_APCC_KENBOX_2	0.3611
p.A473V	SNU-1040	large_intestine	COSMIC	MKENI	DEG_APCC_KENBOX_2	0.2222
p.D470G	NCI-H1417	lung	COSMIC	MKENI	DEG_APCC_KENBOX_2	0.1389
p.N483D	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	MKENI	DEG_APCC_KENBOX_2	0.2778
p.N471D	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	MKENI	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P2E9	Enhancer of mRNA-decapping protein 4	DEG_APCC_KENBOX_2	1081:1085	MKENI	APC,CDC20,FZR1	0.8442	More...
Q9UPW5	Cytosolic carboxypeptidase 1	DEG_APCC_KENBOX_2	477:481	MKENI	APC,CDC20,FZR1	0.605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MKENI

Degron related mutations and impact score

Drug responses associated with AGTPBP1 mutations

All proteins holding degron of MKENI