DegronMD

Uniprot ID: Q6P2E9

Source protein: Enhancer of mRNA-decapping protein 4

Source gene: EDC4

Class: DEG_APCC_DBOX_1

Location: 677:685

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.999

ASA_SCORE: 72.6889

COIL: 0.8348

CONS_SCORE: 0.3157

DSS_SCORE: 0.567

HELIX: 0.1088

FCONS_SCORE: 1.0454

RIG_SCORE: 0.6506

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R678S	TCGA-AA-A01P	COAD	TCGA	PRGLLPGLL	DEG_APCC_DBOX_1	0.7427
p.R678S	DO8642	COAD	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	0.7427
p.S668G	TCGA-BR-4361	STAD	TCGA	PRGLLPGLL	DEG_APCC_DBOX_1	0.0833
p.S668G	DO38887	STAD	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	0.0833
p.A687T	TCGA-CG-5723	STAD	TCGA	PRGLLPGLL	DEG_APCC_DBOX_1	0.2778
p.A687T	DO38376	STAD	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	0.2778
p.P682S	TCGA-D5-6530	COAD	TCGA	PRGLLPGLL	DEG_APCC_DBOX_1	0.5641
p.P682S	DO8312	COAD	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	0.5641
p.P686S	TCGA-EE-A2GO	SKCM	TCGA	PRGLLPGLL	DEG_APCC_DBOX_1	0.3056
p.P686S	DO37823	SKCM	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	0.3056
p.S670N	DO234462	ESAD	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	0.1389
p.A675G	DO230950	LUSC	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	0.2778
p.A675G	DO224638	LUSC	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	0.2778
p.L684P	DO229268	THCA	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	0.7582
p.P688A	SIDM01126	Small Cell Lung Carcinoma	GDSC	PRGLLPGLL	DEG_APCC_DBOX_1	0.25
p.P688A	NCI-H64	lung	COSMIC	PRGLLPGLL	DEG_APCC_DBOX_1	0.25
p.A675E	ACH-001645	Skin Cancer	CCLE	PRGLLPGLL	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P2E9	Enhancer of mRNA-decapping protein 4	DEG_APCC_DBOX_1	677:685	PRGLLPGLL	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons