DegronMD - Q01538(MYT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R501H	TCGA-19-1787	GBM	TCGA	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.0833
p.R501H	DO13522	GBM	ICGC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.0833
p.P693R	TCGA-22-5489	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1944
p.D371Y	TCGA-2H-A9GN	ESCA	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.25
p.G490D	TCGA-2Z-A9JS	KIRP	TCGA	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation altering degron motif	0.6087
p.V41I	TCGA-32-2616	GBM	TCGA	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.1944
p.V41I	TCGA-HU-A4H0	STAD	TCGA	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.1944
p.V41I	DO13462	GBM	ICGC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.1944
p.V41I	DO47785	STAD	ICGC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.1944
p.A682P	TCGA-61-1914	OV	TCGA	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2778
p.A386T	TCGA-69-7761	LUAD	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.2222
p.A386T	DO234446	ESAD	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.2222
p.A386T	DO23620	LUAD	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.2222
p.A386T	ACH-001610	Brain Cancer	CCLE	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.2222
p.M372I	TCGA-78-8662	LUAD	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.2778
p.M372I	DO45346	LUAD	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.2778
p.T36I	TCGA-A5-A1OF	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation altering degron motif	0.8189
p.T36I	DO42568	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation altering degron motif	0.8189
p.A709T	TCGA-AD-6963	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.7139
p.A709T	TCGA-AJ-A8CT	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.7139
p.A709T	SIDM00677	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.7139
p.A709T	ACH-000007	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.7139
p.A709T	LS-513	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.7139
p.A478V	TCGA-AP-A051	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.0833
p.A478V	DO42673	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.0833
p.N498H	TCGA-AP-A0LM	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.1667
p.N498H	DO43306	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.1667
p.K675E	TCGA-B1-A47M	KIRP	TCGA	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation substituting flanking lysine	0.1944
p.K675E	DO49736	KIRP	ICGC	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation substituting flanking lysine	0.1944
p.S706N	TCGA-BG-A222	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.25
p.E22D	TCGA-BR-8680	STAD	TCGA	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.0833
p.E22D	TCGA-DF-A2KV	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.0833
p.E22D	DO47769	STAD	ICGC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.0833
p.E22D	DO219771	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.0833
p.S367P	TCGA-CA-6717	COAD	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1389
p.S367P	DO8264	COAD	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1389
p.E382Q	TCGA-CR-7404	HNSC	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.5633
p.E382Q	DO14420	HNSC	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.5633
p.N681D	TCGA-D1-A103	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.25
p.C30Y	TCGA-D1-A2G0	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.3056
p.C30Y	DO43049	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.3056
p.P21Q	TCGA-D3-A8GL	SKCM	TCGA	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.0556
p.P21Q	DO50287	SKCM	ICGC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.0556
p.A700V	TCGA-D7-6822	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.0833
p.A389V	TCGA-DF-A2KZ	UCEC	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1389
p.A389V	DO52409	UCEC	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1389
p.H674Y	TCGA-DI-A1BU	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.E481K	TCGA-EE-A29E	SKCM	TCGA	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.1667
p.E481K	DO37831	SKCM	ICGC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.1667
p.G39W	TCGA-EO-A22X	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.25
p.G39W	DO43907	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.25
p.P684T	TCGA-ER-A19B	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7031
p.R679L	TCGA-ER-A19P	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1944
p.S688C	TCGA-G9-6366	PRAD	TCGA	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7541
p.S688C	DO36313	PRAD	ICGC	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7541
p.G376R	TCGA-KL-8325	KICH	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.6457
p.G376R	DO220333	KICH	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.6457
p.M373I	TCGA-MN-A4N1	LUAD	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.3056
p.M373I	DO45328	LUAD	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.3056
p.G495S	TCGA-SX-A7SL	KIRP	TCGA	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.25
p.D371N	TCGA-WN-AB4C	KIRP	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.25
p.D371N	DO51570	KIRP	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.25
p.R703H	DO225065	BRCA	ICGC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1667
p.R703H	DO225389	BRCA	ICGC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1667
p.R703H	SIDM01043	Other Sarcomas	GDSC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1667
p.R703H	ACH-000913	Endometrial/Uterine Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1667
p.R703H	ESS-1	endometrium	COSMIC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1667
p.G34A	DO1075	BRCA	ICGC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation altering degron motif	0.6429
p.S374G	DO219737	CESC	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.6993
p.E692K	DO8842	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2222
p.T23N	DO231985	LICA	ICGC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.1111
p.A722D	DO50727	ORCA	ICGC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.0833
p.A709P	DO28105	OV	ICGC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.6392
p.S705C	DO227531	PACA	ICGC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.2222
p.P711T	DO47491	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.7031
p.R381L	DO47623	SKCM	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.8428
p.H701Y	DO42023	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1111
p.N708D	DO42312	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.3056
p.D372E	DO41020	UCEC	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.2778
p.G37C	DO42673	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.3056
p.N498K	SIDM00545	Melanoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.1667
p.N498K	ACH-000987	Skin Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.1667
p.N498K	Mewo	skin	COSMIC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.1667
p.V483A	SIDM01878	Non-Cancerous	GDSC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.2222
p.V483A	SIDM00053	Pancreatic Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.2222
p.V483A	ACH-002360	Non-Cancerous	CCLE	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.2222
p.S38A	SIDM01078	Small Cell Lung Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation blocking phosphorylation signal	0.7222
p.S38A	ACH-000790	Lung Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation blocking phosphorylation signal	0.7222
p.S38A	SHP-77	lung	COSMIC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation blocking phosphorylation signal	0.7222
p.L28I	SIDM00941	Kidney Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.25
p.L28I	CAKI-1	kidney	COSMIC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.25
p.R42W	SIDM00292	Small Cell Lung Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.1667
p.R42W	ACH-002077	Lung Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.1667
p.R42W	LU-165	lung	COSMIC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.1667
p.C491R	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation altering degron motif	0.719
p.C491R	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation altering degron motif	0.719
p.R375W	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.8634
p.S367L	ACH-002348	Non-Cancerous	CCLE	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1389
p.E689D	NCI-H2347	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.3056
p.T501I	HT-115	large intestine	COSMIC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.0833
p.E364D	NCI-H2347	lung	COSMIC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYT1

UniProt ID: Q01538

Entrez ID: 4661

Protein name: Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYT1 in