DegronMD - Q01538(MYT1)

FUNCTION: Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}.

GO - Biological processes (BP): cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]

GO - Molecular function (MF): DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]

GO - Cellular component (CC): chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
TRGNLGLLE	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Myelin transcription factor 1	374:382	More..
PTPGCT	DEG_SCF_FBW7_1	FBXW7	Myelin transcription factor 1	31:36	More..
PTPGCT	DEG_SCF_FBW7_1	FBXW7	Myelin transcription factor 1	487:492	More..
PSSSS	DEG_SPOP_SBC_1	SPOP	Myelin transcription factor 1	684:688	More..
APSSS	DEG_SPOP_SBC_1	SPOP	Myelin transcription factor 1	709:713	More..

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Mutation	Sample	Cancer	Degron hit	Class	Location	Dataset
p.A709T	ACH-000007	Colon/Colorectal Cancer	APSSS	DEG_SPOP_SBC_1	709:713	CCLE
p.S38A	ACH-000790	Lung Cancer	PTPGCT	DEG_SCF_FBW7_1	31:36	CCLE
p.R703H	ACH-000913	Endometrial/Uterine Cancer	APSSS	DEG_SPOP_SBC_1	709:713	CCLE
p.N498K	ACH-000987	Skin Cancer	PTPGCT	DEG_SCF_FBW7_1	487:492	CCLE
p.A386T	ACH-001610	Brain Cancer	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	CCLE
p.R42W	ACH-002077	Lung Cancer	PTPGCT	DEG_SCF_FBW7_1	31:36	CCLE
p.S367L	ACH-002348	Non-Cancerous	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	CCLE
p.V483A	ACH-002360	Non-Cancerous	PTPGCT	DEG_SCF_FBW7_1	487:492	CCLE
p.L28I	CAKI-1	kidney	PTPGCT	DEG_SCF_FBW7_1	31:36	COSMIC
p.G34A	DO1075	BRCA	PTPGCT	DEG_SCF_FBW7_1	31:36	ICGC

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R375W	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.8634
p.R381L	DO47623	SKCM	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.8428
p.T36I	TCGA-A5-A1OF	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation altering degron motif	0.8189
p.T36I	DO42568	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation altering degron motif	0.8189
p.S688C	TCGA-G9-6366	PRAD	TCGA	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7541
p.S688C	DO36313	PRAD	ICGC	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7541
p.S38A	SIDM01078	Small Cell Lung Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation blocking phosphorylation signal	0.7222
p.S38A	ACH-000790	Lung Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation blocking phosphorylation signal	0.7222
p.S38A	SHP-77	lung	COSMIC	PTPGCT	DEG_SCF_FBW7_1	31:36	Mutation blocking phosphorylation signal	0.7222
p.C491R	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation altering degron motif	0.719
p.C491R	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PTPGCT	DEG_SCF_FBW7_1	487:492	Mutation altering degron motif	0.719
p.A709T	TCGA-AD-6963	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.7139
p.A709T	TCGA-AJ-A8CT	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.7139
p.A709T	SIDM00677	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.7139
p.A709T	ACH-000007	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.7139
p.A709T	LS-513	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.7139
p.P684T	TCGA-ER-A19B	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7031
p.P711T	DO47491	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.7031
p.S374G	DO219737	CESC	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.6993
p.G376R	TCGA-KL-8325	KICH	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.6457

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Kaplan plot for MYT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYT1

UniProt ID: Q01538

Entrez ID: 4661

Protein name: Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYT1 in