DegronMD

Uniprot ID: Q01538

Source protein: Myelin transcription factor 1

Source gene: MYT1

Class: DEG_SCF_FBW7_1

Location: 31:36

E3 ligase: FBXW7

DEGRON score: 0.9935

ASA_SCORE: 63.95

COIL: 0.8893

CONS_SCORE: 0.4401

DSS_SCORE: 0.4311

HELIX: 0.0305

FCONS_SCORE: 1.1931

RIG_SCORE: 0.6179

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V41I	TCGA-32-2616	GBM	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.1944
p.V41I	TCGA-HU-A4H0	STAD	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.1944
p.V41I	DO13462	GBM	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.1944
p.V41I	DO47785	STAD	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.1944
p.T36I	TCGA-A5-A1OF	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.8189
p.T36I	DO42568	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.8189
p.E22D	TCGA-BR-8680	STAD	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.E22D	TCGA-DF-A2KV	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.E22D	DO47769	STAD	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.E22D	DO219771	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.C30Y	TCGA-D1-A2G0	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.3056
p.C30Y	DO43049	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.3056
p.P21Q	TCGA-D3-A8GL	SKCM	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.0556
p.P21Q	DO50287	SKCM	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.0556
p.G39W	TCGA-EO-A22X	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.25
p.G39W	DO43907	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.25
p.G34A	DO1075	BRCA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.6429
p.T23N	DO231985	LICA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.1111
p.G37C	DO42673	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.3056
p.S38A	SIDM01078	Small Cell Lung Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.7222
p.S38A	ACH-000790	Lung Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.7222
p.S38A	SHP-77	lung	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.7222
p.L28I	SIDM00941	Kidney Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.25
p.L28I	CAKI-1	kidney	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.25
p.R42W	SIDM00292	Small Cell Lung Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.R42W	ACH-002077	Lung Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.R42W	LU-165	lung	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60284	Suppression of tumorigenicity 18 protein	DEG_SCF_FBW7_1	413:418	PTPGCT	FBXW7	0.9794	More...
Q01538	Myelin transcription factor 1	DEG_SCF_FBW7_1	31:36	PTPGCT	FBXW7	0.9935	More...
Q01538	Myelin transcription factor 1	DEG_SCF_FBW7_1	487:492	PTPGCT	FBXW7	0.9011	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SCF_FBW7_1	551:556	PTPGCT	FBXW7	0.9351	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons