DegronMD - O60284(ST18)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R794C	TCGA-28-1752	GBM	TCGA	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.1667
p.R794C	DO12388	GBM	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.1667
p.G791R	TCGA-3A-A9IH	PAAD	TCGA	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.0833
p.G791R	DO218954	PAAD	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.0833
p.G791R	SIDM00084	Glioblastoma	GDSC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.0833
p.G791R	ACH-000376	Brain Cancer	CCLE	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.0833
p.G791R	SF295	central nervous system	COSMIC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.0833
p.S152I	TCGA-62-A472	LUAD	TCGA	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation altering degron motif	0.7341
p.S152I	DO23639	LUAD	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation altering degron motif	0.7341
p.T647S	TCGA-77-A5G3	LUSC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.2222
p.T647S	DO45456	LUSC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.2222
p.D165H	TCGA-78-7150	LUAD	TCGA	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.0833
p.D165H	TCGA-BH-A2L8	BRCA	TCGA	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.0833
p.D165H	DO44242	BRCA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.0833
p.D165H	DO24411	LUAD	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.0833
p.S856Y	TCGA-78-8662	LUAD	TCGA	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.1944
p.S856Y	DO45346	LUAD	ICGC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.1944
p.R427H	TCGA-85-8071	LUSC	TCGA	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.0833
p.R427H	DO26755	LUSC	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.0833
p.G839C	TCGA-90-A59Q	LUSC	TCGA	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.1111
p.G839C	DO50103	LUSC	ICGC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.1111
p.P413T	TCGA-A4-A5XZ	KIRP	TCGA	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation altering degron motif	0.7031
p.P413T	DO44499	KIRP	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation altering degron motif	0.7031
p.T414M	TCGA-A5-A0GP	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation altering degron motif	0.7423
p.T414M	DO233898	GACA	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation altering degron motif	0.7423
p.T414M	DO41109	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation altering degron motif	0.7423
p.E200D	TCGA-AA-A00N	COAD	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.2222
p.E200D	DO9876	COAD	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.2222
p.L624M	TCGA-AA-A010	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1944
p.L624M	TCGA-B5-A3FC	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1944
p.L624M	DO41871	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1944
p.P817T	TCGA-AG-A01J	READ	TCGA	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.0556
p.P817T	DO36385	READ	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.0556
p.K619E	TCGA-AX-A05Z	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation substituting flanking lysine	0.1667
p.K619E	DO40884	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation substituting flanking lysine	0.1667
p.P640H	TCGA-AX-A1CE	UCEC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7694
p.P640H	DO42280	UCEC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7694
p.R217I	TCGA-AX-A2HC	UCEC	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.1389
p.R217I	DO41572	UCEC	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.1389
p.K806E	TCGA-B5-A11G	UCEC	TCGA	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation altering degron motif	0.591
p.K806E	DO43514	UCEC	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation altering degron motif	0.591
p.S648I	TCGA-B5-A1MX	UCEC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.1944
p.S648I	DO41999	UCEC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.1944
p.E166V	TCGA-BR-6452	STAD	TCGA	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.0556
p.E166V	DO38404	STAD	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.0556
p.S838P	TCGA-CA-6716	COAD	TCGA	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.0833
p.S838P	DO9618	COAD	ICGC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.0833
p.A844V	TCGA-CA-6718	COAD	TCGA	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.25
p.A844V	DO7801	COAD	ICGC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.25
p.R217G	TCGA-CF-A3MG	BLCA	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.1389
p.R217G	DO468	BLCA	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.1389
p.K845N	TCGA-CR-7369	HNSC	TCGA	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.2778
p.K845N	DO14934	HNSC	ICGC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.2778
p.S627Y	TCGA-D1-A103	UCEC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.0556
p.S627Y	TCGA-D1-A103	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.2778
p.S627Y	TCGA-E6-A1LX	UCEC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.0556
p.S627Y	TCGA-E6-A1LX	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.2778
p.S627Y	DO42312	UCEC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.0556
p.S627Y	DO42312	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.2778
p.S627Y	DO41020	UCEC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.0556
p.S627Y	DO41020	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.2778
p.N424K	TCGA-D3-A1Q1	SKCM	TCGA	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.1667
p.N424K	DO37445	SKCM	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.1667
p.E147K	TCGA-D3-A1QA	SKCM	TCGA	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.2222
p.E147K	TCGA-DK-A1A5	BLCA	TCGA	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.2222
p.E147K	TCGA-RP-A693	SKCM	TCGA	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.2222
p.E147K	DO477	BLCA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.2222
p.E147K	DO222595	MELA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.2222
p.E147K	DO222699	MELA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.2222
p.E147K	DO222743	MELA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.2222
p.E147K	DO47469	SKCM	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.2222
p.E147K	DO51268	SKCM	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.2222
p.K214R	TCGA-D3-A3CE	SKCM	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation substituting flanking lysine	0.3333
p.K214R	DO37405	SKCM	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation substituting flanking lysine	0.3333
p.N634K	TCGA-D7-A4YT	STAD	TCGA	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.25
p.N634K	TCGA-D7-A4YT	STAD	TCGA	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.3056
p.N634K	DO47723	STAD	ICGC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.25
p.N634K	DO47723	STAD	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.3056
p.W203C	TCGA-DA-A1IB	SKCM	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.3056
p.W203C	DO38033	SKCM	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.3056
p.D162Y	TCGA-DD-A73F	LIHC	TCGA	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.1667
p.D162Y	DO48587	LIHC	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.1667
p.P216H	TCGA-DU-6392	LGG	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.1667
p.P216H	DO22237	LGG	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.1667
p.S161C	TCGA-DX-A1L2	SARC	TCGA	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.1944
p.S161C	DO219951	SARC	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.1944
p.S141Y	TCGA-E6-A1LX	UCEC	TCGA	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.0556
p.S141Y	DO41020	UCEC	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.0556
p.P851L	TCGA-EB-A3XB	SKCM	TCGA	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation altering degron motif	0.6471
p.P851L	DO37856	SKCM	ICGC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation altering degron motif	0.6471
p.D162N	TCGA-EE-A181	SKCM	TCGA	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.1667
p.D162N	DO37444	SKCM	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.1667
p.G798D	TCGA-EE-A29E	SKCM	TCGA	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.2778
p.G798D	DO37831	SKCM	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.2778
p.R846K	TCGA-EE-A29V	SKCM	TCGA	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.3056
p.R846K	DO38006	SKCM	ICGC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.3056
p.H422Y	TCGA-EE-A2MC	SKCM	TCGA	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.2222
p.H422Y	DO222426	MELA	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.2222
p.H422Y	DO37559	SKCM	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.2222
p.S196F	TCGA-EE-A2MR	SKCM	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.1111
p.S196F	DO220877	MELA	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.1111
p.S196F	DO37819	SKCM	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.1111
p.P851S	TCGA-EE-A3AG	SKCM	TCGA	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation altering degron motif	0.5641
p.P851S	DO37471	SKCM	ICGC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation altering degron motif	0.5641
p.S636Y	TCGA-EO-A22X	UCEC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.3056
p.S636Y	TCGA-EO-A22X	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.25
p.S636Y	TCGA-EO-A3B0	UCEC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.3056
p.S636Y	TCGA-EO-A3B0	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.25
p.S636Y	DO219773	UCEC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.3056
p.S636Y	DO219773	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.25
p.S636Y	DO43907	UCEC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.3056
p.S636Y	DO43907	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.25
p.P415L	TCGA-FD-A5BU	BLCA	TCGA	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation altering degron motif	0.7582
p.P415L	DO44040	BLCA	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation altering degron motif	0.7582
p.P415L	DO228581	GACA	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation altering degron motif	0.7582
p.G419E	TCGA-FR-A3YO	SKCM	TCGA	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.3056
p.G419E	TCGA-FR-A726	SKCM	TCGA	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.3056
p.G419E	DO37419	SKCM	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.3056
p.G419E	DO48665	SKCM	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.3056
p.R622Q	TCGA-FR-A8YC	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.R622Q	DO50301	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.R622Q	SIDM00853	Other Sarcomas	GDSC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.R622Q	GCT	soft tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.S161N	TCGA-FS-A1ZZ	SKCM	TCGA	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.1944
p.S161N	DO37412	SKCM	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.1944
p.R622G	TCGA-GV-A3JZ	BLCA	TCGA	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.R622G	DO773	BLCA	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.M405I	TCGA-HU-A4H8	STAD	TCGA	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.1111
p.M405I	DO47869	STAD	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.1111
p.S632Y	TCGA-NJ-A4YQ	LUAD	TCGA	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation altering degron motif	0.712
p.S632Y	DO218944	LUAD	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation altering degron motif	0.712
p.W859C	TCGA-OR-A5KZ	ACC	TCGA	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.1111
p.P851T	TCGA-V1-A9ZI	PRAD	TCGA	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation altering degron motif	0.5919
p.P851T	DO219399	PRAD	ICGC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation altering degron motif	0.5919
p.G799S	TCGA-WE-A8ZT	SKCM	TCGA	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.3056
p.G799S	DO51290	SKCM	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.3056
p.T639N	DO225357	BRCA	ICGC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7055
p.A795S	DO222821	BTCA	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.1944
p.E810Q	DO222953	BTCA	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.25
p.E166K	DO222884	COCA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.0556
p.L149V	DO222884	COCA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.2778
p.P638Q	DO228978	LICA	ICGC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.5924
p.D811E	DO228971	LICA	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.2222
p.L410I	DO229031	LICA	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.25
p.D165E	DO229035	LICA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.0833
p.T414K	DO229038	LICA	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation altering degron motif	0.7306
p.K860E	DO48760	LIRI	ICGC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation substituting flanking lysine	0.1944
p.I650T	DO231075	LUSC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.1389
p.I650T	SIDM01199	Hepatocellular Carcinoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.1389
p.I650T	SIDM00555	Glioblastoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.1389
p.I650T	SIDM00988	Kidney Carcinoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.1389
p.I650T	SIDM00469	Pancreatic Carcinoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.1389
p.I650T	SIDM00381	Cervical Carcinoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.1389
p.I650T	SIDM00160	Biliary Tract Carcinoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.1389
p.I650T	SIDM01443	Gastric Carcinoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.1389
p.E849K	DO220891	MELA	ICGC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation altering degron motif	0.7022
p.P629L	DO222702	MELA	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation altering degron motif	0.7582
p.P629L	DO229462	SKCA	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation altering degron motif	0.7582
p.R420K	DO222837	MELA	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.2778
p.L403H	DO222837	MELA	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.0556
p.T631A	DO222843	MELA	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation altering degron motif	0.7139
p.R427C	DO46606	OV	ICGC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.0833
p.T803A	DO232761	PBCA	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation altering degron motif	0.7139
p.S632F	DO229462	SKCA	ICGC	PLTSS	DEG_SPOP_SBC_1	629:633	Mutation altering degron motif	0.7982
p.C840F	DO229275	THCA	ICGC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.1389
p.G416E	SIDM01156	Small Cell Lung Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation altering degron motif	0.6087
p.G416E	ACH-000890	Lung Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation altering degron motif	0.6087
p.G416E	SW1271	lung	COSMIC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation altering degron motif	0.6087
p.E211G	SIDM00113	Kidney Carcinoma	GDSC	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.3056
p.E211G	ACH-001208	Kidney Cancer	CCLE	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.3056
p.E211G	TK10	kidney	COSMIC	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.3056
p.L857F	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.1667
p.L857F	SIDM01228	Melanoma	GDSC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.1667
p.L857F	ACH-000482	Lung Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.1667
p.L857F	ACH-001024	Skin Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.1667
p.L857F	RERF-LC-KJ	lung	COSMIC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.1667
p.L857F	CHL-1	skin	COSMIC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.1667
p.N428S	SIDM00487	Colorectal Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.0556
p.N428S	ACH-000963	Colon/Colorectal Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.0556
p.N428S	CCK-81	large intestine	COSMIC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.0556
p.R794H	SIDM00488	Colorectal Carcinoma	GDSC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.1667
p.R794H	CaR-1	large intestine	COSMIC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.1667
p.T647A	SIDM00176	Chondrosarcoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.2222
p.T647A	SIDM01074	Glioblastoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.2222
p.H406Q	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.1389
p.H406Q	ACH-000852	Lung Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.1389
p.H406Q	NCI-H1435	lung	COSMIC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.1389
p.E407G	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.1667
p.E407G	ACH-000371	Lymphoma	CCLE	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.1667
p.E407G	RL	haematopoietic and lymphoid tissue	COSMIC	PTPGCT	DEG_SCF_FBW7_1	413:418	Mutation rewiring degron network	0.1667
p.K860R	SIDM01622	Breast Carcinoma	GDSC	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation substituting flanking lysine	0.1944
p.K860R	ACH-000721	Breast Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation substituting flanking lysine	0.1944
p.P817H	SIDM01611	Endometrial Carcinoma	GDSC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.0556
p.P817H	ACH-000996	Endometrial/Uterine Cancer	CCLE	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.0556
p.P793S	SIDM01611	Endometrial Carcinoma	GDSC	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.1389
p.P793S	ACH-000996	Endometrial/Uterine Cancer	CCLE	VKMTPTKE	DEG_SCF_FBW7_2	800:807	Mutation rewiring degron network	0.1389
p.N148K	SIDM01611	Endometrial Carcinoma	GDSC	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.25
p.N148K	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGIQS	DEG_SCF_TRCP1_1	151:156	Mutation rewiring degron network	0.25
p.G854E	ACH-000659	Lung Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.25
p.G854E	ACH-001386	Lung Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.25
p.S642Y	ACH-001369	Ovarian Cancer	CCLE	IPTPSSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.6009
p.N853D	ACH-001377	Pancreatic Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	847:851	Mutation rewiring degron network	0.2778
p.E200K	ACH-001523	Skin Cancer	CCLE	DSGSNFS	DEG_SCF_TRCP1_1	204:210	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ST18

UniProt ID: O60284

Entrez ID: 9705

Protein name: Suppression of tumorigenicity 18 protein (Zinc finger protein 387)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ST18 in