DegronMD

Uniprot ID: O60284

Source protein: Suppression of tumorigenicity 18 protein

Source gene: ST18

Class: DEG_SCF_FBW7_2

Location: 800:807

E3 ligase: FBXW7

DEGRON score: 0.5373

ASA_SCORE: 108.4125

COIL: 0.8625

CONS_SCORE: 0.3919

DSS_SCORE: 0.5831

HELIX: 0.072

FCONS_SCORE: 0.6929

RIG_SCORE: 0.6839

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T803A	DO232761	PBCA	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	0.7139
p.K806E	TCGA-B5-A11G	UCEC	TCGA	VKMTPTKE	DEG_SCF_FBW7_2	0.591
p.K806E	DO43514	UCEC	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	0.591
p.G799S	TCGA-WE-A8ZT	SKCM	TCGA	VKMTPTKE	DEG_SCF_FBW7_2	0.3056
p.G799S	DO51290	SKCM	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	0.3056
p.G798D	TCGA-EE-A29E	SKCM	TCGA	VKMTPTKE	DEG_SCF_FBW7_2	0.2778
p.G798D	DO37831	SKCM	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	0.2778
p.E810Q	DO222953	BTCA	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	0.25
p.D811E	DO228971	LICA	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	0.2222
p.A795S	DO222821	BTCA	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	0.1944
p.R794C	TCGA-28-1752	GBM	TCGA	VKMTPTKE	DEG_SCF_FBW7_2	0.1667
p.R794C	DO12388	GBM	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	0.1667
p.R794H	SIDM00488	Colorectal Carcinoma	GDSC	VKMTPTKE	DEG_SCF_FBW7_2	0.1667
p.R794H	CaR-1	large_intestine	COSMIC	VKMTPTKE	DEG_SCF_FBW7_2	0.1667
p.P793S	SIDM01611	Endometrial Carcinoma	GDSC	VKMTPTKE	DEG_SCF_FBW7_2	0.1389
p.P793S	ACH-000996	Endometrial/Uterine Cancer	CCLE	VKMTPTKE	DEG_SCF_FBW7_2	0.1389
p.G791R	TCGA-3A-A9IH	PAAD	TCGA	VKMTPTKE	DEG_SCF_FBW7_2	0.0833
p.G791R	DO218954	PAAD	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	0.0833
p.G791R	SIDM00084	Glioblastoma	GDSC	VKMTPTKE	DEG_SCF_FBW7_2	0.0833
p.G791R	ACH-000376	Brain Cancer	CCLE	VKMTPTKE	DEG_SCF_FBW7_2	0.0833
p.G791R	SF295	central_nervous_system	COSMIC	VKMTPTKE	DEG_SCF_FBW7_2	0.0833
p.P817T	TCGA-AG-A01J	READ	TCGA	VKMTPTKE	DEG_SCF_FBW7_2	0.0556
p.P817T	DO36385	READ	ICGC	VKMTPTKE	DEG_SCF_FBW7_2	0.0556
p.P817H	SIDM01611	Endometrial Carcinoma	GDSC	VKMTPTKE	DEG_SCF_FBW7_2	0.0556
p.P817H	ACH-000996	Endometrial/Uterine Cancer	CCLE	VKMTPTKE	DEG_SCF_FBW7_2	0.0556

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Drug responses associated with ST18 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VKMTPTKE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60284	Suppression of tumorigenicity 18 protein	DEG_SCF_FBW7_2	800:807	VKMTPTKE	FBXW7	0.5373	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKMTPTKE

Degron related mutations and impact score

Drug responses associated with ST18 mutations

All proteins holding degron of VKMTPTKE