DegronMD

Uniprot ID: O60284

Source protein: Suppression of tumorigenicity 18 protein

Source gene: ST18

Class: DEG_SCF_TRCP1_1

Location: 204:210

E3 ligase: BTRC

DEGRON score: 0.9989

ASA_SCORE: 81.9714

COIL: 0.8583

CONS_SCORE: 0.4434

DSS_SCORE: 0.6508

HELIX: 0.1173

FCONS_SCORE: 1.3933

RIG_SCORE: 0.5829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E200D	TCGA-AA-A00N	COAD	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	0.2222
p.E200D	DO9876	COAD	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	0.2222
p.R217I	TCGA-AX-A2HC	UCEC	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	0.1389
p.R217I	DO41572	UCEC	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	0.1389
p.R217G	TCGA-CF-A3MG	BLCA	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	0.1389
p.R217G	DO468	BLCA	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	0.1389
p.K214R	TCGA-D3-A3CE	SKCM	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	0.3333
p.K214R	DO37405	SKCM	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	0.3333
p.W203C	TCGA-DA-A1IB	SKCM	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	0.3056
p.W203C	DO38033	SKCM	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	0.3056
p.P216H	TCGA-DU-6392	LGG	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	0.1667
p.P216H	DO22237	LGG	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	0.1667
p.S196F	TCGA-EE-A2MR	SKCM	TCGA	DSGSNFS	DEG_SCF_TRCP1_1	0.1111
p.S196F	DO220877	MELA	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	0.1111
p.S196F	DO37819	SKCM	ICGC	DSGSNFS	DEG_SCF_TRCP1_1	0.1111
p.E211G	SIDM00113	Kidney Carcinoma	GDSC	DSGSNFS	DEG_SCF_TRCP1_1	0.3056
p.E211G	ACH-001208	Kidney Cancer	CCLE	DSGSNFS	DEG_SCF_TRCP1_1	0.3056
p.E211G	TK10	kidney	COSMIC	DSGSNFS	DEG_SCF_TRCP1_1	0.3056
p.E200K	ACH-001523	Skin Cancer	CCLE	DSGSNFS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60284	Suppression of tumorigenicity 18 protein	DEG_SCF_TRCP1_1	204:210	DSGSNFS	BTRC	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons