DegronMD

Uniprot ID: O60284

Source protein: Suppression of tumorigenicity 18 protein

Source gene: ST18

Class: DEG_SCF_FBW7_1

Location: 413:418

E3 ligase: FBXW7

DEGRON score: 0.9794

ASA_SCORE: 67.0167

COIL: 0.9468

CONS_SCORE: 0.7933

DSS_SCORE: 0.2969

HELIX: 0.0163

FCONS_SCORE: 1.2714

RIG_SCORE: 0.6938

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R427H	TCGA-85-8071	LUSC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.R427H	DO26755	LUSC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.P413T	TCGA-A4-A5XZ	KIRP	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.7031
p.P413T	DO44499	KIRP	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7031
p.T414M	TCGA-A5-A0GP	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.7423
p.T414M	DO233898	GACA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7423
p.T414M	DO41109	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7423
p.N424K	TCGA-D3-A1Q1	SKCM	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.N424K	DO37445	SKCM	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.H422Y	TCGA-EE-A2MC	SKCM	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.2222
p.H422Y	DO222426	MELA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.2222
p.H422Y	DO37559	SKCM	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.2222
p.P415L	TCGA-FD-A5BU	BLCA	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.7582
p.P415L	DO44040	BLCA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7582
p.P415L	DO228581	GACA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7582
p.G419E	TCGA-FR-A3YO	SKCM	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.3056
p.G419E	TCGA-FR-A726	SKCM	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.3056
p.G419E	DO37419	SKCM	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.3056
p.G419E	DO48665	SKCM	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.3056
p.M405I	TCGA-HU-A4H8	STAD	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.1111
p.M405I	DO47869	STAD	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.1111
p.L410I	DO229031	LICA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.25
p.T414K	DO229038	LICA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7306
p.R420K	DO222837	MELA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.2778
p.L403H	DO222837	MELA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.0556
p.R427C	DO46606	OV	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.G416E	SIDM01156	Small Cell Lung Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.6087
p.G416E	ACH-000890	Lung Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.6087
p.G416E	SW1271	lung	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.6087
p.N428S	SIDM00487	Colorectal Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.0556
p.N428S	ACH-000963	Colon/Colorectal Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.0556
p.N428S	CCK-81	large_intestine	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.0556
p.H406Q	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.1389
p.H406Q	ACH-000852	Lung Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.1389
p.H406Q	NCI-H1435	lung	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.1389
p.E407G	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.E407G	ACH-000371	Lymphoma	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.E407G	RL	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60284	Suppression of tumorigenicity 18 protein	DEG_SCF_FBW7_1	413:418	PTPGCT	FBXW7	0.9794	More...
Q01538	Myelin transcription factor 1	DEG_SCF_FBW7_1	31:36	PTPGCT	FBXW7	0.9935	More...
Q01538	Myelin transcription factor 1	DEG_SCF_FBW7_1	487:492	PTPGCT	FBXW7	0.9011	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SCF_FBW7_1	551:556	PTPGCT	FBXW7	0.9351	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPGCT

Degron related mutations and impact score

Drug responses associated with ST18 mutations

All proteins holding degron of PTPGCT