DegronMD

Uniprot ID: Q01538

Source protein: Myelin transcription factor 1

Source gene: MYT1

Class: DEG_SCF_FBW7_1

Location: 487:492

E3 ligase: FBXW7

DEGRON score: 0.9011

ASA_SCORE: 62

COIL: 0.8795

CONS_SCORE: 0.772

DSS_SCORE: 0.3397

HELIX: 0.0237

FCONS_SCORE: 1.2269

RIG_SCORE: 0.6681

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R501H	TCGA-19-1787	GBM	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.R501H	DO13522	GBM	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.G490D	TCGA-2Z-A9JS	KIRP	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.6087
p.A478V	TCGA-AP-A051	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.A478V	DO42673	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.N498H	TCGA-AP-A0LM	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.N498H	DO43306	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.E481K	TCGA-EE-A29E	SKCM	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.E481K	DO37831	SKCM	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.G495S	TCGA-SX-A7SL	KIRP	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.25
p.N498K	SIDM00545	Melanoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.N498K	ACH-000987	Skin Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.N498K	Mewo	skin	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.1667
p.V483A	SIDM01878	Non-Cancerous	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.2222
p.V483A	SIDM00053	Pancreatic Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.2222
p.V483A	ACH-002360	Non-Cancerous	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.2222
p.C491R	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.719
p.C491R	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.719
p.T501I	HT-115	large_intestine	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60284	Suppression of tumorigenicity 18 protein	DEG_SCF_FBW7_1	413:418	PTPGCT	FBXW7	0.9794	More...
Q01538	Myelin transcription factor 1	DEG_SCF_FBW7_1	31:36	PTPGCT	FBXW7	0.9935	More...
Q01538	Myelin transcription factor 1	DEG_SCF_FBW7_1	487:492	PTPGCT	FBXW7	0.9011	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SCF_FBW7_1	551:556	PTPGCT	FBXW7	0.9351	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons