DegronMD

Uniprot ID: Q9UL68

Source protein: Myelin transcription factor 1-like protein

Source gene: MYT1L

Class: DEG_SCF_FBW7_1

Location: 551:556

E3 ligase: FBXW7

DEGRON score: 0.9351

ASA_SCORE: 61.35

COIL: 0.8665

CONS_SCORE: 0.7149

DSS_SCORE: 0.3499

HELIX: 0.0265

FCONS_SCORE: 1.262

RIG_SCORE: 0.6631

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G552C	TCGA-37-4141	LUSC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.76
p.G552C	DO26862	LUSC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.76
p.R556S	TCGA-77-8133	LUSC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.7427
p.R556S	DO27039	LUSC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7427
p.T554M	TCGA-AA-3864	COAD	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.7423
p.T554M	TCGA-XF-A9SG	BLCA	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.7423
p.T554M	DO51912	BLCA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7423
p.T554M	DO8490	COAD	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7423
p.T554M	DO222285	GACA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7423
p.T554M	DO233843	GACA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7423
p.P551L	TCGA-AJ-A3BH	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.6471
p.P551L	DO225337	BRCA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.6471
p.P551L	DO41638	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.6471
p.P551L	ACH-000941	Endometrial/Uterine Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.6471
p.P551L	ACH-000954	Endometrial/Uterine Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.6471
p.R556C	TCGA-AP-A051	UCEC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.8301
p.R556C	DO42673	UCEC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.8301
p.R556C	ACH-001610	Brain Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.8301
p.R556H	TCGA-DX-A6YS	SARC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.8244
p.R556H	TCGA-EK-A2H0	CESC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.8244
p.R556H	TCGA-MK-A4N7	THCA	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.8244
p.R556H	DO49020	CESC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.8244
p.R556H	DO220005	SARC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.8244
p.R556H	DO39404	THCA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.8244
p.T554K	TCGA-L9-A7SV	LUAD	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.7306
p.T554K	DO229025	LICA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7306
p.T554K	DO49875	LUAD	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.7306
p.L546F	TCGA-NK-A5CR	LUSC	TCGA	PTPGCT	DEG_SCF_FBW7_1	0.1944
p.L546F	DO219207	LUSC	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.1944
p.H566Q	DO228974	LICA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.0556
p.N560K	DO229035	LICA	ICGC	PTPGCT	DEG_SCF_FBW7_1	0.2222
p.C550F	SIDM00427	Ewing's Sarcoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.3056
p.C550F	RH-1	soft_tissue	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.3056
p.A542V	SIDM00534	Colorectal Carcinoma	GDSC	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.A542V	HT-115	large_intestine	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.0833
p.P551T	ACH-001416	Bladder Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.7031
p.C548F	ACH-002194	Bone Cancer	CCLE	PTPGCT	DEG_SCF_FBW7_1	0.25
p.C548F	RH-1	soft_tissue	COSMIC	PTPGCT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60284	Suppression of tumorigenicity 18 protein	DEG_SCF_FBW7_1	413:418	PTPGCT	FBXW7	0.9794	More...
Q01538	Myelin transcription factor 1	DEG_SCF_FBW7_1	31:36	PTPGCT	FBXW7	0.9935	More...
Q01538	Myelin transcription factor 1	DEG_SCF_FBW7_1	487:492	PTPGCT	FBXW7	0.9011	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SCF_FBW7_1	551:556	PTPGCT	FBXW7	0.9351	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPGCT

Degron related mutations and impact score

Drug responses associated with MYT1L mutations

All proteins holding degron of PTPGCT