DegronMD

Uniprot ID: O60284

Source protein: Suppression of tumorigenicity 18 protein

Source gene: ST18

Class: DEG_SCF_TRCP1_1

Location: 151:156

E3 ligase: BTRC

DEGRON score: 0.8984

ASA_SCORE: 85.65

COIL: 0.6708

CONS_SCORE: 0.332

DSS_SCORE: 0.4766

HELIX: 0.2973

FCONS_SCORE: 0.9956

RIG_SCORE: 0.7265

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S152I	TCGA-62-A472	LUAD	TCGA	DSGIQS	DEG_SCF_TRCP1_1	0.7341
p.S152I	DO23639	LUAD	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.7341
p.D165H	TCGA-78-7150	LUAD	TCGA	DSGIQS	DEG_SCF_TRCP1_1	0.0833
p.D165H	TCGA-BH-A2L8	BRCA	TCGA	DSGIQS	DEG_SCF_TRCP1_1	0.0833
p.D165H	DO44242	BRCA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.0833
p.D165H	DO24411	LUAD	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.0833
p.E166V	TCGA-BR-6452	STAD	TCGA	DSGIQS	DEG_SCF_TRCP1_1	0.0556
p.E166V	DO38404	STAD	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.0556
p.E147K	TCGA-D3-A1QA	SKCM	TCGA	DSGIQS	DEG_SCF_TRCP1_1	0.2222
p.E147K	TCGA-DK-A1A5	BLCA	TCGA	DSGIQS	DEG_SCF_TRCP1_1	0.2222
p.E147K	TCGA-RP-A693	SKCM	TCGA	DSGIQS	DEG_SCF_TRCP1_1	0.2222
p.E147K	DO477	BLCA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.2222
p.E147K	DO222595	MELA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.2222
p.E147K	DO222699	MELA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.2222
p.E147K	DO222743	MELA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.2222
p.E147K	DO47469	SKCM	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.2222
p.E147K	DO51268	SKCM	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.2222
p.D162Y	TCGA-DD-A73F	LIHC	TCGA	DSGIQS	DEG_SCF_TRCP1_1	0.1667
p.D162Y	DO48587	LIHC	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.1667
p.S161C	TCGA-DX-A1L2	SARC	TCGA	DSGIQS	DEG_SCF_TRCP1_1	0.1944
p.S161C	DO219951	SARC	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.1944
p.S141Y	TCGA-E6-A1LX	UCEC	TCGA	DSGIQS	DEG_SCF_TRCP1_1	0.0556
p.S141Y	DO41020	UCEC	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.0556
p.D162N	TCGA-EE-A181	SKCM	TCGA	DSGIQS	DEG_SCF_TRCP1_1	0.1667
p.D162N	DO37444	SKCM	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.1667
p.S161N	TCGA-FS-A1ZZ	SKCM	TCGA	DSGIQS	DEG_SCF_TRCP1_1	0.1944
p.S161N	DO37412	SKCM	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.1944
p.E166K	DO222884	COCA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.0556
p.L149V	DO222884	COCA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.2778
p.D165E	DO229035	LICA	ICGC	DSGIQS	DEG_SCF_TRCP1_1	0.0833
p.N148K	SIDM01611	Endometrial Carcinoma	GDSC	DSGIQS	DEG_SCF_TRCP1_1	0.25
p.N148K	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGIQS	DEG_SCF_TRCP1_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGIQS

Degron related mutations and impact score

Drug responses associated with ST18 mutations

All proteins holding degron of DSGIQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60284	Suppression of tumorigenicity 18 protein	DEG_SCF_TRCP1_1	151:156	DSGIQS	BTRC	0.8984	More...