DegronMD

Uniprot ID: O60284

Source protein: Suppression of tumorigenicity 18 protein

Source gene: ST18

Class: DEG_SCF_FBW7_1

Location: 637:643

E3 ligase: FBXW7

DEGRON score: 0.9948

ASA_SCORE: 77.7857

COIL: 0.964

CONS_SCORE: 0.4472

DSS_SCORE: 0.4912

HELIX: 0.0144

FCONS_SCORE: 1.0673

RIG_SCORE: 0.62

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T647S	TCGA-77-A5G3	LUSC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	0.2222
p.T647S	DO45456	LUSC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	0.2222
p.P640H	TCGA-AX-A1CE	UCEC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	0.7694
p.P640H	DO42280	UCEC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	0.7694
p.S648I	TCGA-B5-A1MX	UCEC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	0.1944
p.S648I	DO41999	UCEC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	0.1944
p.S627Y	TCGA-D1-A103	UCEC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	0.0556
p.S627Y	TCGA-E6-A1LX	UCEC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	0.0556
p.S627Y	DO42312	UCEC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	0.0556
p.S627Y	DO41020	UCEC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	0.0556
p.N634K	TCGA-D7-A4YT	STAD	TCGA	IPTPSSS	DEG_SCF_FBW7_1	0.25
p.N634K	DO47723	STAD	ICGC	IPTPSSS	DEG_SCF_FBW7_1	0.25
p.S636Y	TCGA-EO-A22X	UCEC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	0.3056
p.S636Y	TCGA-EO-A3B0	UCEC	TCGA	IPTPSSS	DEG_SCF_FBW7_1	0.3056
p.S636Y	DO219773	UCEC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	0.3056
p.S636Y	DO43907	UCEC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	0.3056
p.T639N	DO225357	BRCA	ICGC	IPTPSSS	DEG_SCF_FBW7_1	0.7055
p.P638Q	DO228978	LICA	ICGC	IPTPSSS	DEG_SCF_FBW7_1	0.5924
p.I650T	DO231075	LUSC	ICGC	IPTPSSS	DEG_SCF_FBW7_1	0.1389
p.I650T	SIDM01199	Hepatocellular Carcinoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	0.1389
p.I650T	SIDM00555	Glioblastoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	0.1389
p.I650T	SIDM00988	Kidney Carcinoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	0.1389
p.I650T	SIDM00469	Pancreatic Carcinoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	0.1389
p.I650T	SIDM00381	Cervical Carcinoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	0.1389
p.I650T	SIDM00160	Biliary Tract Carcinoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	0.1389
p.I650T	SIDM01443	Gastric Carcinoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	0.1389
p.T647A	SIDM00176	Chondrosarcoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	0.2222
p.T647A	SIDM01074	Glioblastoma	GDSC	IPTPSSS	DEG_SCF_FBW7_1	0.2222
p.S642Y	ACH-001369	Ovarian Cancer	CCLE	IPTPSSS	DEG_SCF_FBW7_1	0.6009

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPTPSSS

Degron related mutations and impact score

Drug responses associated with ST18 mutations

All proteins holding degron of IPTPSSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60284	Suppression of tumorigenicity 18 protein	DEG_SCF_FBW7_1	637:643	IPTPSSS	FBXW7	0.9948	More...