DegronMD

Uniprot ID: O60284

Source protein: Suppression of tumorigenicity 18 protein

Source gene: ST18

Class: DEG_APCC_KENBOX_2

Location: 847:851

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8117

ASA_SCORE: 101.6

COIL: 0.8366

CONS_SCORE: 0.4106

DSS_SCORE: 0.4254

HELIX: 0.126

FCONS_SCORE: 0.9165

RIG_SCORE: 0.6987

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S856Y	TCGA-78-8662	LUAD	TCGA	QKENP	DEG_APCC_KENBOX_2	0.1944
p.S856Y	DO45346	LUAD	ICGC	QKENP	DEG_APCC_KENBOX_2	0.1944
p.G839C	TCGA-90-A59Q	LUSC	TCGA	QKENP	DEG_APCC_KENBOX_2	0.1111
p.G839C	DO50103	LUSC	ICGC	QKENP	DEG_APCC_KENBOX_2	0.1111
p.S838P	TCGA-CA-6716	COAD	TCGA	QKENP	DEG_APCC_KENBOX_2	0.0833
p.S838P	DO9618	COAD	ICGC	QKENP	DEG_APCC_KENBOX_2	0.0833
p.A844V	TCGA-CA-6718	COAD	TCGA	QKENP	DEG_APCC_KENBOX_2	0.25
p.A844V	DO7801	COAD	ICGC	QKENP	DEG_APCC_KENBOX_2	0.25
p.K845N	TCGA-CR-7369	HNSC	TCGA	QKENP	DEG_APCC_KENBOX_2	0.2778
p.K845N	DO14934	HNSC	ICGC	QKENP	DEG_APCC_KENBOX_2	0.2778
p.P851L	TCGA-EB-A3XB	SKCM	TCGA	QKENP	DEG_APCC_KENBOX_2	0.6471
p.P851L	DO37856	SKCM	ICGC	QKENP	DEG_APCC_KENBOX_2	0.6471
p.R846K	TCGA-EE-A29V	SKCM	TCGA	QKENP	DEG_APCC_KENBOX_2	0.3056
p.R846K	DO38006	SKCM	ICGC	QKENP	DEG_APCC_KENBOX_2	0.3056
p.P851S	TCGA-EE-A3AG	SKCM	TCGA	QKENP	DEG_APCC_KENBOX_2	0.5641
p.P851S	DO37471	SKCM	ICGC	QKENP	DEG_APCC_KENBOX_2	0.5641
p.W859C	TCGA-OR-A5KZ	ACC	TCGA	QKENP	DEG_APCC_KENBOX_2	0.1111
p.P851T	TCGA-V1-A9ZI	PRAD	TCGA	QKENP	DEG_APCC_KENBOX_2	0.5919
p.P851T	DO219399	PRAD	ICGC	QKENP	DEG_APCC_KENBOX_2	0.5919
p.K860E	DO48760	LIRI	ICGC	QKENP	DEG_APCC_KENBOX_2	0.1944
p.E849K	DO220891	MELA	ICGC	QKENP	DEG_APCC_KENBOX_2	0.7022
p.C840F	DO229275	THCA	ICGC	QKENP	DEG_APCC_KENBOX_2	0.1389
p.L857F	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	QKENP	DEG_APCC_KENBOX_2	0.1667
p.L857F	SIDM01228	Melanoma	GDSC	QKENP	DEG_APCC_KENBOX_2	0.1667
p.L857F	ACH-000482	Lung Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	0.1667
p.L857F	ACH-001024	Skin Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	0.1667
p.L857F	RERF-LC-KJ	lung	COSMIC	QKENP	DEG_APCC_KENBOX_2	0.1667
p.L857F	CHL-1	skin	COSMIC	QKENP	DEG_APCC_KENBOX_2	0.1667
p.K860R	SIDM01622	Breast Carcinoma	GDSC	QKENP	DEG_APCC_KENBOX_2	0.1944
p.K860R	ACH-000721	Breast Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	0.1944
p.G854E	ACH-000659	Lung Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	0.25
p.G854E	ACH-001386	Lung Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	0.25
p.N853D	ACH-001377	Pancreatic Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60284	Suppression of tumorigenicity 18 protein	DEG_APCC_KENBOX_2	847:851	QKENP	APC,CDC20,FZR1	0.8117	More...
O60721	Sodium/potassium/calcium exchanger 1	DEG_APCC_KENBOX_2	737:741	QKENP	APC,CDC20,FZR1	0.7728	More...
Q8TAT5	Endonuclease 8-like 3	DEG_APCC_KENBOX_2	280:284	QKENP	APC,CDC20,FZR1	0.624	More...
Q8WVJ2	NudC domain-containing protein 2	DEG_APCC_KENBOX_2	128:132	QKENP	APC,CDC20,FZR1	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QKENP

Degron related mutations and impact score

Drug responses associated with ST18 mutations

All proteins holding degron of QKENP