DegronMD - Q8WVJ2(NUDCD2)

FUNCTION: May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. {ECO:0000269|PubMed:20133715}.

GO - Biological processes (BP): protein folding [GO:0006457]

GO - Molecular function (MF): unfolded protein binding [GO:0051082]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
QKENP	DEG_APCC_KENBOX_2	APC,CDC20,FZR1	NudC domain-containing protein 2	128:132	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S128L	CP66-MEL	skin	COSMIC	QKENP	DEG_APCC_KENBOX_2	128:132	Mutation altering degron motif	0.7667
p.E131Q	DO47723	STAD	ICGC	QKENP	DEG_APCC_KENBOX_2	128:132	Mutation altering degron motif	0.6744
p.F127I	TCGA-DX-A8BP	SARC	TCGA	QKENP	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.3056
p.D126N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	QKENP	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.2778
p.E125Q	TCGA-78-7149	LUAD	TCGA	QKENP	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.25
p.G124E	DO50329	ESAD	ICGC	QKENP	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.2222
p.R120K	TCGA-DF-A2KU	UCEC	TCGA	QKENP	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.1111
p.N119Y	DO1579	BRCA	ICGC	QKENP	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.0833

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No resistance data available for this Degron.

Kaplan plot for NUDCD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUDCD2

UniProt ID: Q8WVJ2

Entrez ID: 134492

Protein name: NudC domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for NUDCD2 in