DegronMD

Uniprot ID: Q8WVJ2

Source protein: NudC domain-containing protein 2

Source gene: NUDCD2

Class: DEG_APCC_KENBOX_2

Location: 128:132

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9986

ASA_SCORE: 107.04

COIL: 0.8054

CONS_SCORE: 0.6701

DSS_SCORE: 0.4308

HELIX: 0.1652

FCONS_SCORE: 1.0385

RIG_SCORE: 0.7292

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E125Q	TCGA-78-7149	LUAD	TCGA	QKENP	DEG_APCC_KENBOX_2	0.25
p.R120K	TCGA-DF-A2KU	UCEC	TCGA	QKENP	DEG_APCC_KENBOX_2	0.1111
p.F127I	TCGA-DX-A8BP	SARC	TCGA	QKENP	DEG_APCC_KENBOX_2	0.3056
p.N119Y	DO1579	BRCA	ICGC	QKENP	DEG_APCC_KENBOX_2	0.0833
p.G124E	DO50329	ESAD	ICGC	QKENP	DEG_APCC_KENBOX_2	0.2222
p.E131Q	DO47723	STAD	ICGC	QKENP	DEG_APCC_KENBOX_2	0.6744
p.D126N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	QKENP	DEG_APCC_KENBOX_2	0.2778
p.S128L	CP66-MEL	skin	COSMIC	QKENP	DEG_APCC_KENBOX_2	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60284	Suppression of tumorigenicity 18 protein	DEG_APCC_KENBOX_2	847:851	QKENP	APC,CDC20,FZR1	0.8117	More...
O60721	Sodium/potassium/calcium exchanger 1	DEG_APCC_KENBOX_2	737:741	QKENP	APC,CDC20,FZR1	0.7728	More...
Q8TAT5	Endonuclease 8-like 3	DEG_APCC_KENBOX_2	280:284	QKENP	APC,CDC20,FZR1	0.624	More...
Q8WVJ2	NudC domain-containing protein 2	DEG_APCC_KENBOX_2	128:132	QKENP	APC,CDC20,FZR1	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons