DegronMD - O60721(SLC24A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T167A	TCGA-AA-A02R	COAD	TCGA	PTPRGE	DEG_SCF_FBW7_2	168:173	Mutation blocking phosphorylation signal	0.75
p.S178N	TCGA-AJ-A3BH	UCEC	TCGA	PTPRGE	DEG_SCF_FBW7_2	168:173	Mutation rewiring degron network	0.1944
p.S178N	DO41638	UCEC	ICGC	PTPRGE	DEG_SCF_FBW7_2	168:173	Mutation rewiring degron network	0.1944
p.V730A	TCGA-AP-A0LM	UCEC	TCGA	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.6936
p.A227T	TCGA-AX-A1CE	UCEC	TCGA	ITPRTT	DEG_SCF_FBW7_1	214:219	Mutation rewiring degron network	0.1111
p.A227T	DO42280	UCEC	ICGC	ITPRTT	DEG_SCF_FBW7_1	214:219	Mutation rewiring degron network	0.1111
p.L298S	TCGA-B5-A11E	UCEC	TCGA	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.1667
p.L298S	DO41644	UCEC	ICGC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.1667
p.A414S	TCGA-B5-A11E	UCEC	TCGA	MLTTPSPS	DEG_SCF_FBW7_1	403:410	Mutation rewiring degron network	0.2222
p.A414S	DO41644	UCEC	ICGC	MLTTPSPS	DEG_SCF_FBW7_1	403:410	Mutation rewiring degron network	0.2222
p.A385E	TCGA-CQ-A4CI	HNSC	TCGA	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1389
p.A385E	DO49063	HNSC	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1389
p.P721S	TCGA-DF-A2KN	UCEC	TCGA	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation rewiring degron network	0.25
p.A385T	TCGA-DF-A2KU	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1389
p.A385T	DO223286	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1389
p.L312R	TCGA-DI-A1BU	UCEC	TCGA	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation altering degron motif	0.8428
p.L312R	DO42023	UCEC	ICGC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation altering degron motif	0.8428
p.G297V	TCGA-E7-A4IJ	BLCA	TCGA	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.1389
p.G297V	DO453	BLCA	ICGC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.1389
p.P295S	TCGA-EB-A44O	SKCM	TCGA	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.0833
p.P295S	DO47272	SKCM	ICGC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.0833
p.G321R	TCGA-EE-A2MS	SKCM	TCGA	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.2778
p.G321R	DO37567	SKCM	ICGC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.2778
p.G309E	TCGA-EE-A3J3	SKCM	TCGA	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.6087
p.G309E	DO48652	SKCM	ICGC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.6087
p.T215A	TCGA-FI-A2D0	UCEC	TCGA	ITPRTT	DEG_SCF_FBW7_1	214:219	Mutation altering degron motif	0.7139
p.T215A	DO43891	UCEC	ICGC	ITPRTT	DEG_SCF_FBW7_1	214:219	Mutation altering degron motif	0.7139
p.Q308H	TCGA-G4-6320	COAD	TCGA	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.647
p.Q308H	DO8159	COAD	ICGC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.647
p.P307L	TCGA-GN-A4U4	SKCM	TCGA	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7582
p.P307L	TCGA-W3-AA21	SKCM	TCGA	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7582
p.P307L	DO51278	SKCM	ICGC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7582
p.P307L	DO51256	SKCM	ICGC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7582
p.P304L	TCGA-HU-A4GU	STAD	TCGA	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.6471
p.P304L	DO47849	STAD	ICGC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.6471
p.A213V	DO227987	COCA	ICGC	ITPRTT	DEG_SCF_FBW7_1	214:219	Mutation rewiring degron network	0.3056
p.L313V	DO229010	COCA	ICGC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation altering degron motif	0.5654
p.L313V	DO229505	LAML	ICGC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation altering degron motif	0.5654
p.E733K	DO50326	ESAD	ICGC	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.7022
p.E744K	DO11782	GBM	ICGC	QKENP	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.25
p.E744K	DO43306	UCEC	ICGC	QKENP	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.25
p.T380I	DO228908	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.2778
p.D728Y	DO229041	LICA	ICGC	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.7325
p.N722K	DO231821	LINC	ICGC	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation rewiring degron network	0.2778
p.A317D	DO50727	ORCA	ICGC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation altering degron motif	0.6682
p.W296S	DO48938	PBCA	ICGC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.1111
p.E741K	DO50075	UCEC	ICGC	QKENP	DEG_APCC_KENBOX_2	737:741	Mutation altering degron motif	0.7022
p.V311L	SIDM00499	Prostate Carcinoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00499	Prostate Carcinoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM00422	Hodgkin's Lymphoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00422	Hodgkin's Lymphoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM00845	Burkitt's Lymphoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00845	Burkitt's Lymphoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM00854	Burkitt's Lymphoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00854	Burkitt's Lymphoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM00694	Other Solid Cancers	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00694	Other Solid Cancers	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM00254	Neuroblastoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00254	Neuroblastoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM01064	Hodgkin's Lymphoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM01064	Hodgkin's Lymphoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM00310	Mesothelioma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00310	Mesothelioma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM00668	Non-Cancerous	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00668	Non-Cancerous	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.V311L	SIDM00721	Small Cell Lung Carcinoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00721	Small Cell Lung Carcinoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.3056
p.T400N	SIDM00373	Endometrial Carcinoma	GDSC	MLTTPSPS	DEG_SCF_FBW7_1	403:410	Mutation rewiring degron network	0.25
p.E749K	SIDM00234	Other Solid Cancers	GDSC	QKENP	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1111
p.E749K	ACH-002201	Cervical Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1111
p.E749K	TC-YIK	cervix	COSMIC	QKENP	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1111
p.A728V	SIDM00222	Mesothelioma	GDSC	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.5825
p.A728V	MPP-89	pleura	COSMIC	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.5825
p.T724M	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.8534
p.A728P	SIDM01205	Acute Myeloid Leukemia	GDSC	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.6392
p.A728P	SIDM01195	Acute Myeloid Leukemia	GDSC	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.6392
p.A728P	ACH-000406	Leukemia	CCLE	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.6392
p.A728P	ACH-002314	Leukemia	CCLE	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.6392
p.A728P	TUR	haematopoietic and lymphoid tissue	COSMIC	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.6392
p.S326R	SIDM01664	Prostate Carcinoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	312:319	Mutation rewiring degron network	0.1389
p.A748T	ACH-000999	Colon/Colorectal Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1389
p.E731K	TC-YIK	cervix	COSMIC	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.7022
p.N729H	HCC2998	large intestine	COSMIC	TVTPAPVPDI	DEG_COP1_1	724:733	Mutation altering degron motif	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC24A1

UniProt ID: O60721

Entrez ID: 9187

Protein name: Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger) (Solute carrier family 24 member 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC24A1 in