DegronMD

Uniprot ID: O60721

Source protein: Sodium/potassium/calcium exchanger 1

Source gene: SLC24A1

Class: DEG_SCF_FBW7_1

Location: 312:319

E3 ligase: FBXW7

DEGRON score: 0.9944

ASA_SCORE: 68.8375

COIL: 0.7391

CONS_SCORE: 0.3349

DSS_SCORE: 0.615

HELIX: 0.1133

FCONS_SCORE: 1.0566

RIG_SCORE: 0.7388

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L312R	TCGA-DI-A1BU	UCEC	TCGA	LLHTPATS	DEG_SCF_FBW7_1	0.8428
p.L312R	DO42023	UCEC	ICGC	LLHTPATS	DEG_SCF_FBW7_1	0.8428
p.G321R	TCGA-EE-A2MS	SKCM	TCGA	LLHTPATS	DEG_SCF_FBW7_1	0.2778
p.G321R	DO37567	SKCM	ICGC	LLHTPATS	DEG_SCF_FBW7_1	0.2778
p.L313V	DO229010	COCA	ICGC	LLHTPATS	DEG_SCF_FBW7_1	0.5654
p.L313V	DO229505	LAML	ICGC	LLHTPATS	DEG_SCF_FBW7_1	0.5654
p.A317D	DO50727	ORCA	ICGC	LLHTPATS	DEG_SCF_FBW7_1	0.6682
p.V311L	SIDM00499	Prostate Carcinoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00422	Hodgkin's Lymphoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00845	Burkitt's Lymphoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00854	Burkitt's Lymphoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00694	Other Solid Cancers	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00254	Neuroblastoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM01064	Hodgkin's Lymphoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00310	Mesothelioma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00668	Non-Cancerous	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00721	Small Cell Lung Carcinoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.3056
p.S326R	SIDM01664	Prostate Carcinoma	GDSC	LLHTPATS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60721	Sodium/potassium/calcium exchanger 1	DEG_SCF_FBW7_1	312:319	LLHTPATS	FBXW7	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLHTPATS

Degron related mutations and impact score

Drug responses associated with SLC24A1 mutations

All proteins holding degron of LLHTPATS