DegronMD

Uniprot ID: O60721

Source protein: Sodium/potassium/calcium exchanger 1

Source gene: SLC24A1

Class: DEG_COP1_1

Location: 724:733

E3 ligase: COP1

DEGRON score: 0.9959

ASA_SCORE: 75.05

COIL: 0.8161

CONS_SCORE: 0.3959

DSS_SCORE: 0.7034

HELIX: 0.0409

FCONS_SCORE: 1.0089

RIG_SCORE: 0.6738

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T724M	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	TVTPAPVPDI	DEG_COP1_1	0.8534
p.N729H	HCC2998	large_intestine	COSMIC	TVTPAPVPDI	DEG_COP1_1	0.7423
p.D728Y	DO229041	LICA	ICGC	TVTPAPVPDI	DEG_COP1_1	0.7325
p.E733K	DO50326	ESAD	ICGC	TVTPAPVPDI	DEG_COP1_1	0.7022
p.E731K	TC-YIK	cervix	COSMIC	TVTPAPVPDI	DEG_COP1_1	0.7022
p.V730A	TCGA-AP-A0LM	UCEC	TCGA	TVTPAPVPDI	DEG_COP1_1	0.6936
p.A728P	SIDM01205	Acute Myeloid Leukemia	GDSC	TVTPAPVPDI	DEG_COP1_1	0.6392
p.A728P	SIDM01195	Acute Myeloid Leukemia	GDSC	TVTPAPVPDI	DEG_COP1_1	0.6392
p.A728P	ACH-000406	Leukemia	CCLE	TVTPAPVPDI	DEG_COP1_1	0.6392
p.A728P	ACH-002314	Leukemia	CCLE	TVTPAPVPDI	DEG_COP1_1	0.6392
p.A728P	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	TVTPAPVPDI	DEG_COP1_1	0.6392
p.A728V	SIDM00222	Mesothelioma	GDSC	TVTPAPVPDI	DEG_COP1_1	0.5825
p.A728V	MPP-89	pleura	COSMIC	TVTPAPVPDI	DEG_COP1_1	0.5825
p.N722K	DO231821	LINC	ICGC	TVTPAPVPDI	DEG_COP1_1	0.2778
p.P721S	TCGA-DF-A2KN	UCEC	TCGA	TVTPAPVPDI	DEG_COP1_1	0.25

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60721	Sodium/potassium/calcium exchanger 1	DEG_COP1_1	724:733	TVTPAPVPDI	COP1	0.9959	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons