DegronMD

Uniprot ID: O60721

Source protein: Sodium/potassium/calcium exchanger 1

Source gene: SLC24A1

Class: DEG_SCF_FBW7_2

Location: 168:173

E3 ligase: FBXW7

DEGRON score: 0.9899

ASA_SCORE: 85.8167

COIL: 0.845

CONS_SCORE: 0.3434

DSS_SCORE: 0.5739

HELIX: 0.07

FCONS_SCORE: 0.9859

RIG_SCORE: 0.6696

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T167A	TCGA-AA-A02R	COAD	TCGA	PTPRGE	DEG_SCF_FBW7_2	0.75
p.S178N	TCGA-AJ-A3BH	UCEC	TCGA	PTPRGE	DEG_SCF_FBW7_2	0.1944
p.S178N	DO41638	UCEC	ICGC	PTPRGE	DEG_SCF_FBW7_2	0.1944

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60721	Sodium/potassium/calcium exchanger 1	DEG_SCF_FBW7_2	168:173	PTPRGE	FBXW7	0.9899	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons