DegronMD

Uniprot ID: O60721

Source protein: Sodium/potassium/calcium exchanger 1

Source gene: SLC24A1

Class: DEG_SCF_FBW7_1

Location: 403:410

E3 ligase: FBXW7

DEGRON score: 0.974

ASA_SCORE: 87.4875

COIL: 0.937

CONS_SCORE: 0.3898

DSS_SCORE: 0.4697

HELIX: 0.0264

FCONS_SCORE: 1.0481

RIG_SCORE: 0.7028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A414S	TCGA-B5-A11E	UCEC	TCGA	MLTTPSPS	DEG_SCF_FBW7_1	0.2222
p.A414S	DO41644	UCEC	ICGC	MLTTPSPS	DEG_SCF_FBW7_1	0.2222
p.T400N	SIDM00373	Endometrial Carcinoma	GDSC	MLTTPSPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60721	Sodium/potassium/calcium exchanger 1	DEG_SCF_FBW7_1	403:410	MLTTPSPS	FBXW7	0.974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons