DegronMD

Uniprot ID: O60721

Source protein: Sodium/potassium/calcium exchanger 1

Source gene: SLC24A1

Class: DEG_SCF_FBW7_1

Location: 214:219

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 74.85

COIL: 0.7278

CONS_SCORE: 0.3663

DSS_SCORE: 0.4581

HELIX: 0.021

FCONS_SCORE: 1.1766

RIG_SCORE: 0.7739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A227T	TCGA-AX-A1CE	UCEC	TCGA	ITPRTT	DEG_SCF_FBW7_1	0.1111
p.A227T	DO42280	UCEC	ICGC	ITPRTT	DEG_SCF_FBW7_1	0.1111
p.T215A	TCGA-FI-A2D0	UCEC	TCGA	ITPRTT	DEG_SCF_FBW7_1	0.7139
p.T215A	DO43891	UCEC	ICGC	ITPRTT	DEG_SCF_FBW7_1	0.7139
p.A213V	DO227987	COCA	ICGC	ITPRTT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60721	Sodium/potassium/calcium exchanger 1	DEG_SCF_FBW7_1	214:219	ITPRTT	FBXW7	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons