DegronMD

Uniprot ID: O60721

Source protein: Sodium/potassium/calcium exchanger 1

Source gene: SLC24A1

Class: DEG_APCC_KENBOX_2

Location: 737:741

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7728

ASA_SCORE: 98.5

COIL: 0.7866

CONS_SCORE: 0.3964

DSS_SCORE: 0.8426

HELIX: 0.0636

FCONS_SCORE: 1.0575

RIG_SCORE: 0.5841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E744K	DO11782	GBM	ICGC	QKENP	DEG_APCC_KENBOX_2	0.25
p.E744K	DO43306	UCEC	ICGC	QKENP	DEG_APCC_KENBOX_2	0.25
p.E741K	DO50075	UCEC	ICGC	QKENP	DEG_APCC_KENBOX_2	0.7022
p.E749K	SIDM00234	Other Solid Cancers	GDSC	QKENP	DEG_APCC_KENBOX_2	0.1111
p.E749K	ACH-002201	Cervical Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	0.1111
p.E749K	TC-YIK	cervix	COSMIC	QKENP	DEG_APCC_KENBOX_2	0.1111
p.A748T	ACH-000999	Colon/Colorectal Cancer	CCLE	QKENP	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60284	Suppression of tumorigenicity 18 protein	DEG_APCC_KENBOX_2	847:851	QKENP	APC,CDC20,FZR1	0.8117	More...
O60721	Sodium/potassium/calcium exchanger 1	DEG_APCC_KENBOX_2	737:741	QKENP	APC,CDC20,FZR1	0.7728	More...
Q8TAT5	Endonuclease 8-like 3	DEG_APCC_KENBOX_2	280:284	QKENP	APC,CDC20,FZR1	0.624	More...
Q8WVJ2	NudC domain-containing protein 2	DEG_APCC_KENBOX_2	128:132	QKENP	APC,CDC20,FZR1	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons