DegronMD

Uniprot ID: Q8TAT5

Source protein: Endonuclease 8-like 3

Source gene: NEIL3

Class: DEG_APCC_KENBOX_2

Location: 280:284

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.624

ASA_SCORE: 81.6

COIL: 0.8544

CONS_SCORE: 0.4694

DSS_SCORE: 0.0333

HELIX: 0.0646

FCONS_SCORE: 0.8793

RIG_SCORE: 0.7576

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V287G	TCGA-B5-A3FA	UCEC	TCGA	QKENP	DEG_APCC_KENBOX_2	0.25
p.V287G	DO52402	UCEC	ICGC	QKENP	DEG_APCC_KENBOX_2	0.25
p.P284S	TCGA-D3-A8GL	SKCM	TCGA	QKENP	DEG_APCC_KENBOX_2	0.5641
p.P284S	DO50287	SKCM	ICGC	QKENP	DEG_APCC_KENBOX_2	0.5641
p.T273S	TCGA-HU-8602	STAD	TCGA	QKENP	DEG_APCC_KENBOX_2	0.1389
p.T273S	DO47829	STAD	ICGC	QKENP	DEG_APCC_KENBOX_2	0.1389
p.H286R	DO229505	LAML	ICGC	QKENP	DEG_APCC_KENBOX_2	0.2778
p.C290Y	DO229050	LICA	ICGC	QKENP	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60284	Suppression of tumorigenicity 18 protein	DEG_APCC_KENBOX_2	847:851	QKENP	APC,CDC20,FZR1	0.8117	More...
O60721	Sodium/potassium/calcium exchanger 1	DEG_APCC_KENBOX_2	737:741	QKENP	APC,CDC20,FZR1	0.7728	More...
Q8TAT5	Endonuclease 8-like 3	DEG_APCC_KENBOX_2	280:284	QKENP	APC,CDC20,FZR1	0.624	More...
Q8WVJ2	NudC domain-containing protein 2	DEG_APCC_KENBOX_2	128:132	QKENP	APC,CDC20,FZR1	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons