DegronMD

Uniprot ID: O60721

Source protein: Sodium/potassium/calcium exchanger 1

Source gene: SLC24A1

Class: DEG_SCF_FBW7_1

Location: 304:310

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 70.5429

COIL: 0.8187

CONS_SCORE: 0.3249

DSS_SCORE: 0.6203

HELIX: 0.083

FCONS_SCORE: 1.0765

RIG_SCORE: 0.6436

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L298S	TCGA-B5-A11E	UCEC	TCGA	PKTPQGT	DEG_SCF_FBW7_1	0.1667
p.L298S	DO41644	UCEC	ICGC	PKTPQGT	DEG_SCF_FBW7_1	0.1667
p.G297V	TCGA-E7-A4IJ	BLCA	TCGA	PKTPQGT	DEG_SCF_FBW7_1	0.1389
p.G297V	DO453	BLCA	ICGC	PKTPQGT	DEG_SCF_FBW7_1	0.1389
p.P295S	TCGA-EB-A44O	SKCM	TCGA	PKTPQGT	DEG_SCF_FBW7_1	0.0833
p.P295S	DO47272	SKCM	ICGC	PKTPQGT	DEG_SCF_FBW7_1	0.0833
p.G309E	TCGA-EE-A3J3	SKCM	TCGA	PKTPQGT	DEG_SCF_FBW7_1	0.6087
p.G309E	DO48652	SKCM	ICGC	PKTPQGT	DEG_SCF_FBW7_1	0.6087
p.Q308H	TCGA-G4-6320	COAD	TCGA	PKTPQGT	DEG_SCF_FBW7_1	0.647
p.Q308H	DO8159	COAD	ICGC	PKTPQGT	DEG_SCF_FBW7_1	0.647
p.P307L	TCGA-GN-A4U4	SKCM	TCGA	PKTPQGT	DEG_SCF_FBW7_1	0.7582
p.P307L	TCGA-W3-AA21	SKCM	TCGA	PKTPQGT	DEG_SCF_FBW7_1	0.7582
p.P307L	DO51278	SKCM	ICGC	PKTPQGT	DEG_SCF_FBW7_1	0.7582
p.P307L	DO51256	SKCM	ICGC	PKTPQGT	DEG_SCF_FBW7_1	0.7582
p.P304L	TCGA-HU-A4GU	STAD	TCGA	PKTPQGT	DEG_SCF_FBW7_1	0.6471
p.P304L	DO47849	STAD	ICGC	PKTPQGT	DEG_SCF_FBW7_1	0.6471
p.W296S	DO48938	PBCA	ICGC	PKTPQGT	DEG_SCF_FBW7_1	0.1111
p.V311L	SIDM00499	Prostate Carcinoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00422	Hodgkin's Lymphoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00845	Burkitt's Lymphoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00854	Burkitt's Lymphoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00694	Other Solid Cancers	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00254	Neuroblastoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM01064	Hodgkin's Lymphoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00310	Mesothelioma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00668	Non-Cancerous	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056
p.V311L	SIDM00721	Small Cell Lung Carcinoma	GDSC	PKTPQGT	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKTPQGT

Degron related mutations and impact score

Drug responses associated with SLC24A1 mutations

All proteins holding degron of PKTPQGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60721	Sodium/potassium/calcium exchanger 1	DEG_SCF_FBW7_1	304:310	PKTPQGT	FBXW7	0.9959	More...