DegronMD

Uniprot ID: Q01538

Source protein: Myelin transcription factor 1

Source gene: MYT1

Class: DEG_APCC_DBOX_1

Location: 374:382

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7638

ASA_SCORE: 83.0444

COIL: 0.557

CONS_SCORE: 0.377

DSS_SCORE: 0.4497

HELIX: 0.4148

FCONS_SCORE: 0.9925

RIG_SCORE: 0.7799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D371Y	TCGA-2H-A9GN	ESCA	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	0.25
p.A386T	TCGA-69-7761	LUAD	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	0.2222
p.A386T	DO234446	ESAD	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	0.2222
p.A386T	DO23620	LUAD	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	0.2222
p.A386T	ACH-001610	Brain Cancer	CCLE	TRGNLGLLE	DEG_APCC_DBOX_1	0.2222
p.M372I	TCGA-78-8662	LUAD	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	0.2778
p.M372I	DO45346	LUAD	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	0.2778
p.S367P	TCGA-CA-6717	COAD	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	0.1389
p.S367P	DO8264	COAD	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	0.1389
p.E382Q	TCGA-CR-7404	HNSC	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	0.5633
p.E382Q	DO14420	HNSC	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	0.5633
p.A389V	TCGA-DF-A2KZ	UCEC	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	0.1389
p.A389V	DO52409	UCEC	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	0.1389
p.G376R	TCGA-KL-8325	KICH	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	0.6457
p.G376R	DO220333	KICH	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	0.6457
p.M373I	TCGA-MN-A4N1	LUAD	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	0.3056
p.M373I	DO45328	LUAD	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	0.3056
p.D371N	TCGA-WN-AB4C	KIRP	TCGA	TRGNLGLLE	DEG_APCC_DBOX_1	0.25
p.D371N	DO51570	KIRP	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	0.25
p.S374G	DO219737	CESC	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	0.6993
p.R381L	DO47623	SKCM	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	0.8428
p.D372E	DO41020	UCEC	ICGC	TRGNLGLLE	DEG_APCC_DBOX_1	0.2778
p.R375W	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	TRGNLGLLE	DEG_APCC_DBOX_1	0.8634
p.S367L	ACH-002348	Non-Cancerous	CCLE	TRGNLGLLE	DEG_APCC_DBOX_1	0.1389
p.E364D	NCI-H2347	lung	COSMIC	TRGNLGLLE	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01538	Myelin transcription factor 1	DEG_APCC_DBOX_1	374:382	TRGNLGLLE	APC,CDC20,FZR1	0.7638	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons