DegronMD - Q14694(USP10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P156S	TCGA-AA-3864	COAD	TCGA	PPGY	ITCH	156:159	Mutation altering degron motif	0.6752
p.R26Q	TCGA-AP-A0LM	UCEC	TCGA	VTPRSS	DEG_SCF_FBW7_1	23:28	Mutation altering degron motif	0.6218
p.R26Q	DO43306	UCEC	ICGC	VTPRSS	DEG_SCF_FBW7_1	23:28	Mutation altering degron motif	0.6218
p.L83P	TCGA-D1-A174	UCEC	TCGA	LPRTPSYS	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.1944
p.L71F	TCGA-D8-A1JF	BRCA	TCGA	LPRTPSYS	DEG_SCF_FBW7_1	71:78	Mutation altering degron motif	0.6981
p.L71F	DO6204	BRCA	ICGC	LPRTPSYS	DEG_SCF_FBW7_1	71:78	Mutation altering degron motif	0.6981
p.E30D	TCGA-DF-A2KN	UCEC	TCGA	VTPRSS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.2778
p.Y160C	TCGA-DI-A1BU	UCEC	TCGA	PPGY	ITCH	156:159	Mutation blocking phosphorylation signal	0.75
p.E63K	TCGA-DK-AA6W	BLCA	TCGA	LPRTPSYS	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.1111
p.S161I	TCGA-DU-6392	LGG	TCGA	PPGY	ITCH	156:159	Mutation blocking phosphorylation signal	0.7222
p.P15L	TCGA-EE-A29A	SKCM	TCGA	VTPRSS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.1111
p.P15L	DO37416	SKCM	ICGC	VTPRSS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.1111
p.F13V	TCGA-F5-6814	READ	TCGA	VTPRSS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.0556
p.F13V	DO36556	READ	ICGC	VTPRSS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.0556
p.P85S	TCGA-FW-A3R5	SKCM	TCGA	LPRTPSYS	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.1389
p.P85S	DO37406	SKCM	ICGC	LPRTPSYS	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.1389
p.S349Y	TCGA-HE-7128	KIRP	TCGA	PSSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.2778
p.E67K	DO219009	BLCA	ICGC	LPRTPSYS	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.2222
p.P160S	DO8490	COAD	ICGC	PPGY	ITCH	156:159	Mutation blocking phosphorylation signal	0.75
p.K154Q	DO222798	COCA	ICGC	PPGY	ITCH	156:159	Mutation blocking ubiquitination signal	0.7222
p.L349H	DO10811	EOPC	ICGC	PSSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.2778
p.H351Y	DO50450	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.7229
p.S353Y	DO20796	KIRP	ICGC	PSSSS	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.712
p.S165I	DO22237	LGG	ICGC	PPGY	ITCH	156:159	Mutation rewiring degron network	0.1667
p.D69H	DO228886	LICA	ICGC	LPRTPSYS	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.2778
p.A87S	DO229018	LICA	ICGC	LPRTPSYS	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.0833
p.G146C	DO229026	LICA	ICGC	PPGY	ITCH	156:159	Mutation rewiring degron network	0.0556
p.D352Y	DO229037	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.7325
p.L87P	DO40900	UCEC	ICGC	LPRTPSYS	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.0833
p.Y164C	DO42023	UCEC	ICGC	PPGY	ITCH	156:159	Mutation substituting flanking lysine	0.3056
p.E34D	DO223282	UCEC	ICGC	VTPRSS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.1667
p.K344R	SIDM00602	Gastric Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1389
p.K344R	IM-95	stomach	COSMIC	PSSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1389
p.S341I	SIDM00095	Glioblastoma	GDSC	PSSSS	DEG_SPOP_SBC_1	351:355	Mutation blocking phosphorylation signal	0.5
p.E365A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	351:355	Mutation blocking phosphorylation signal	0.5
p.E365A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	351:355	Mutation blocking phosphorylation signal	0.5
p.E365A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	351:355	Mutation blocking phosphorylation signal	0.5
p.R153H	SIDM00710	Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	156:159	Mutation substituting flanking lysine	0.3611
p.R153H	SIDM01102	Non-Cancerous	GDSC	PPGY	ITCH	156:159	Mutation substituting flanking lysine	0.3611
p.R153H	SIDM00124	Kidney Carcinoma	GDSC	PPGY	ITCH	156:159	Mutation substituting flanking lysine	0.3611
p.R153H	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	156:159	Mutation substituting flanking lysine	0.3611
p.R153H	A498	kidney	COSMIC	PPGY	ITCH	156:159	Mutation substituting flanking lysine	0.3611
p.R153H	NCI-H2081	lung	COSMIC	PPGY	ITCH	156:159	Mutation substituting flanking lysine	0.3611
p.S32L	SIDM00528	Breast Carcinoma	GDSC	VTPRSS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.2222
p.S32L	MDA-MB-361	breast	COSMIC	VTPRSS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.2222
p.P161R	SIDM00201	Ewing's Sarcoma	GDSC	PPGY	ITCH	156:159	Mutation blocking phosphorylation signal	0.7222
p.P161R	EW-7	bone	COSMIC	PPGY	ITCH	156:159	Mutation blocking phosphorylation signal	0.7222
p.S28L	ACH-000934	Breast Cancer	CCLE	VTPRSS	DEG_SCF_FBW7_1	23:28	Mutation altering degron motif	0.7667
p.S28L	MDA-MB-361	breast	COSMIC	VTPRSS	DEG_SCF_FBW7_1	23:28	Mutation altering degron motif	0.7667
p.P157R	ACH-002119	Bone Cancer	CCLE	PPGY	ITCH	156:159	Mutation altering degron motif	0.7512
p.P157R	EW-7	bone	COSMIC	PPGY	ITCH	156:159	Mutation altering degron motif	0.7512
p.R149H	NCI-H2081	lung	COSMIC	PPGY	ITCH	156:159	Mutation rewiring degron network	0.1389
p.R149H	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	156:159	Mutation rewiring degron network	0.1389
p.R149H	A498	kidney	COSMIC	PPGY	ITCH	156:159	Mutation rewiring degron network	0.1389

Kaplan plot for USP10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP10

UniProt ID: Q14694

Entrez ID: 9100

Protein name: Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP10 in