DegronMD

Uniprot ID: Q14694

Source protein: Ubiquitin carboxyl-terminal hydrolase 10

Source gene: USP10

Class: DEG_SCF_FBW7_1

Location: 23:28

E3 ligase: FBXW7

DEGRON score: 0.9873

ASA_SCORE: 57.9333

COIL: 0.6997

CONS_SCORE: 0.3704

DSS_SCORE: 0.3296

HELIX: 0.0275

FCONS_SCORE: 0.9431

RIG_SCORE: 0.7824

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R26Q	TCGA-AP-A0LM	UCEC	TCGA	VTPRSS	DEG_SCF_FBW7_1	0.6218
p.R26Q	DO43306	UCEC	ICGC	VTPRSS	DEG_SCF_FBW7_1	0.6218
p.E30D	TCGA-DF-A2KN	UCEC	TCGA	VTPRSS	DEG_SCF_FBW7_1	0.2778
p.P15L	TCGA-EE-A29A	SKCM	TCGA	VTPRSS	DEG_SCF_FBW7_1	0.1111
p.P15L	DO37416	SKCM	ICGC	VTPRSS	DEG_SCF_FBW7_1	0.1111
p.F13V	TCGA-F5-6814	READ	TCGA	VTPRSS	DEG_SCF_FBW7_1	0.0556
p.F13V	DO36556	READ	ICGC	VTPRSS	DEG_SCF_FBW7_1	0.0556
p.E34D	DO223282	UCEC	ICGC	VTPRSS	DEG_SCF_FBW7_1	0.1667
p.S32L	SIDM00528	Breast Carcinoma	GDSC	VTPRSS	DEG_SCF_FBW7_1	0.2222
p.S32L	MDA-MB-361	breast	COSMIC	VTPRSS	DEG_SCF_FBW7_1	0.2222
p.S28L	ACH-000934	Breast Cancer	CCLE	VTPRSS	DEG_SCF_FBW7_1	0.7667
p.S28L	MDA-MB-361	breast	COSMIC	VTPRSS	DEG_SCF_FBW7_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14694	Ubiquitin carboxyl-terminal hydrolase 10	DEG_SCF_FBW7_1	23:28	VTPRSS	FBXW7	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons