DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LPRTPSYS
Uniprot ID:
Q14694
Source protein:
Ubiquitin carboxyl-terminal hydrolase 10
Source gene:
USP10
Class:
DEG_SCF_FBW7_1
Location:
71:78
E3 ligase:
FBXW7
DEGRON score:
0.9973
ASA_SCORE:
80.275
COIL:
0.9143
CONS_SCORE:
0.3676
DSS_SCORE:
0.5463
HELIX:
0.022
FCONS_SCORE:
0.9149
RIG_SCORE:
0.7127
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L83P
TCGA-D1-A174
UCEC
TCGA
LPRTPSYS
DEG_SCF_FBW7_1
0.1944
p.L71F
TCGA-D8-A1JF
BRCA
TCGA
LPRTPSYS
DEG_SCF_FBW7_1
0.6981
p.L71F
DO6204
BRCA
ICGC
LPRTPSYS
DEG_SCF_FBW7_1
0.6981
p.E63K
TCGA-DK-AA6W
BLCA
TCGA
LPRTPSYS
DEG_SCF_FBW7_1
0.1111
p.P85S
TCGA-FW-A3R5
SKCM
TCGA
LPRTPSYS
DEG_SCF_FBW7_1
0.1389
p.P85S
DO37406
SKCM
ICGC
LPRTPSYS
DEG_SCF_FBW7_1
0.1389
p.E67K
DO219009
BLCA
ICGC
LPRTPSYS
DEG_SCF_FBW7_1
0.2222
p.D69H
DO228886
LICA
ICGC
LPRTPSYS
DEG_SCF_FBW7_1
0.2778
p.A87S
DO229018
LICA
ICGC
LPRTPSYS
DEG_SCF_FBW7_1
0.0833
p.L87P
DO40900
UCEC
ICGC
LPRTPSYS
DEG_SCF_FBW7_1
0.0833
Drug responses associated with USP10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPRTPSYS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14694
Ubiquitin carboxyl-terminal hydrolase 10
DEG_SCF_FBW7_1
71:78
LPRTPSYS
FBXW7
0.9973
More...