DegronMD

Uniprot ID: Q14694

Source protein: Ubiquitin carboxyl-terminal hydrolase 10

Source gene: USP10

Class: DEG_SCF_FBW7_1

Location: 71:78

E3 ligase: FBXW7

DEGRON score: 0.9973

ASA_SCORE: 80.275

COIL: 0.9143

CONS_SCORE: 0.3676

DSS_SCORE: 0.5463

HELIX: 0.022

FCONS_SCORE: 0.9149

RIG_SCORE: 0.7127

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L71F	TCGA-D8-A1JF	BRCA	TCGA	LPRTPSYS	DEG_SCF_FBW7_1	0.6981
p.L71F	DO6204	BRCA	ICGC	LPRTPSYS	DEG_SCF_FBW7_1	0.6981
p.D69H	DO228886	LICA	ICGC	LPRTPSYS	DEG_SCF_FBW7_1	0.2778
p.E67K	DO219009	BLCA	ICGC	LPRTPSYS	DEG_SCF_FBW7_1	0.2222
p.L83P	TCGA-D1-A174	UCEC	TCGA	LPRTPSYS	DEG_SCF_FBW7_1	0.1944
p.P85S	TCGA-FW-A3R5	SKCM	TCGA	LPRTPSYS	DEG_SCF_FBW7_1	0.1389
p.P85S	DO37406	SKCM	ICGC	LPRTPSYS	DEG_SCF_FBW7_1	0.1389
p.E63K	TCGA-DK-AA6W	BLCA	TCGA	LPRTPSYS	DEG_SCF_FBW7_1	0.1111
p.A87S	DO229018	LICA	ICGC	LPRTPSYS	DEG_SCF_FBW7_1	0.0833
p.L87P	DO40900	UCEC	ICGC	LPRTPSYS	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14694	Ubiquitin carboxyl-terminal hydrolase 10	DEG_SCF_FBW7_1	71:78	LPRTPSYS	FBXW7	0.9973	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons