DegronMD

Uniprot ID: Q14694

Source protein: Ubiquitin carboxyl-terminal hydrolase 10

Source gene: USP10

Class: DEG_SPOP_SBC_1

Location: 351:355

E3 ligase: SPOP

DEGRON score: 0.9991

ASA_SCORE: 77.48

COIL: 0.9556

CONS_SCORE: 0.4062

DSS_SCORE: 0.3785

HELIX: 0.0306

FCONS_SCORE: 0.9919

RIG_SCORE: 0.5629

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D352Y	DO229037	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.7325
p.H351Y	DO50450	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	0.7229
p.S353Y	DO20796	KIRP	ICGC	PSSSS	DEG_SPOP_SBC_1	0.712
p.S341I	SIDM00095	Glioblastoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.5
p.E365A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.5
p.E365A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.5
p.E365A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.5
p.S349Y	TCGA-HE-7128	KIRP	TCGA	PSSSS	DEG_SPOP_SBC_1	0.2778
p.L349H	DO10811	EOPC	ICGC	PSSSS	DEG_SPOP_SBC_1	0.2778
p.K344R	SIDM00602	Gastric Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.1389
p.K344R	IM-95	stomach	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.1389

Showing 1 to 11 of 11 entries

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Drug responses associated with USP10 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PSSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1276:1280	PSSSS	SPOP	0.9293	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	698:702	PSSSS	SPOP	0.9524	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	832:836	PSSSS	SPOP	0.995	More...
O95996	Adenomatous polyposis coli protein 2	DEG_SPOP_SBC_1	1144:1148	PSSSS	SPOP	0.9971	More...
O95996	Adenomatous polyposis coli protein 2	DEG_SPOP_SBC_1	1872:1876	PSSSS	SPOP	0.9707	More...
Q9Y4X0	AMME syndrome candidate gene 1 protein	DEG_SPOP_SBC_1	108:112	PSSSS	SPOP	0.7876	More...
P48751	Anion exchange protein 3	DEG_SPOP_SBC_1	441:445	PSSSS	SPOP	0.9863	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	2295:2299	PSSSS	SPOP	0.9846	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	863:867	PSSSS	SPOP	0.9942	More...
P29374	AT-rich interactive domain-containing protein 4A	DEG_SPOP_SBC_1	1242:1246	PSSSS	SPOP	0.9873	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_SPOP_SBC_1	1281:1285	PSSSS	SPOP	0.6698	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	214:218	PSSSS	SPOP	0.7612	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	841:845	PSSSS	SPOP	0.9975	More...
Q16585	Beta-sarcoglycan	DEG_SPOP_SBC_1	269:273	PSSSS	SPOP	0.5268	More...
O94983	Calmodulin-binding transcription activator 2	DEG_SPOP_SBC_1	290:294	PSSSS	SPOP	0.9979	More...
Q9UDT6	CAP-Gly domain-containing linker protein 2	DEG_SPOP_SBC_1	315:319	PSSSS	SPOP	0.9467	More...
O75052	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein	DEG_SPOP_SBC_1	272:276	PSSSS	SPOP	0.9973	More...
Q9NQ75	Cas scaffolding protein family member 4	DEG_SPOP_SBC_1	273:277	PSSSS	SPOP	0.999	More...
Q9H3Q1	Cdc42 effector protein 4	DEG_SPOP_SBC_1	69:73	PSSSS	SPOP	0.9451	More...
Q76N32	Centrosomal protein of 68 kDa	DEG_SPOP_SBC_1	531:535	PSSSS	SPOP	0.864	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	2080:2084	PSSSS	SPOP	0.9952	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	151:155	PSSSS	SPOP	0.9715	More...
P38432	Coilin	DEG_SPOP_SBC_1	244:248	PSSSS	SPOP	0.9884	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	358:362	PSSSS	SPOP	0.8546	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	301:305	PSSSS	SPOP	0.6405	More...

Showing 1 to 25 of 159 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSSS

Degron related mutations and impact score

Drug responses associated with USP10 mutations

All proteins holding degron of PSSSS