DegronMD - Q9UMR3(TBX20)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P362T	TCGA-A1-A0SO	BRCA	TCGA	VSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1111
p.P362T	DO2020	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1111
p.G72D	TCGA-B5-A3FA	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.25
p.G72D	DO52402	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.25
p.E83D	TCGA-CM-6171	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2222
p.E83D	DO8151	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2222
p.E327K	TCGA-CQ-6218	HNSC	TCGA	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0556
p.E327K	DO14180	HNSC	ICGC	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0556
p.S336L	TCGA-DM-A1HA	COAD	TCGA	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.3056
p.S336L	DO8754	COAD	ICGC	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.3056
p.P332T	TCGA-EE-A181	SKCM	TCGA	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1944
p.P332T	DO37444	SKCM	ICGC	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1944
p.H361N	DO228986	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1389
p.S351T	SIDM00680	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	350:354	Mutation altering degron motif	0.6005
p.S351T	ACH-000957	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	350:354	Mutation altering degron motif	0.6005
p.S351T	LS-180	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	350:354	Mutation altering degron motif	0.6005
p.N333S	SIDM00652	Small Cell Lung Carcinoma	GDSC	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2222
p.N333S	ACH-000780	Lung Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2222
p.N333S	NCI-H1105	lung	COSMIC	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2222
p.T331A	SIDM00315	Glioblastoma	GDSC	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1667
p.T331A	SIDM01469	Pancreatic Carcinoma	GDSC	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1667
p.T331A	ACH-000085	Pancreatic Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1667
p.T331A	ACH-000570	Brain Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1667
p.T331A	YKG-1	central nervous system	COSMIC	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1667
p.G335V	SIDM00552	Rhabdomyosarcoma	GDSC	AFTTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2778
p.G358A	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.2222
p.G358A	ACH-000481	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.2222
p.G358A	NCI-H2170	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.2222
p.G358W	SIDM01118	Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.2222
p.G358W	ACH-002175	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.2222
p.G358W	NCI-H740	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.2222
p.S77Y	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	75:79	Mutation altering degron motif	0.712
p.S77Y	ACH-000900	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	75:79	Mutation altering degron motif	0.712
p.S77Y	NCI-H23	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	75:79	Mutation altering degron motif	0.712
p.G70C	ACH-000954	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.1944
p.S78F	ACH-001568	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	75:79	Mutation altering degron motif	0.7982

Kaplan plot for TBX20 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBX20

UniProt ID: Q9UMR3

Entrez ID: 57057

Protein name: T-box transcription factor TBX20 (T-box protein 20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBX20 in