DegronMD

Uniprot ID: Q9UMR3

Source protein: T-box transcription factor TBX20

Source gene: TBX20

Class: DEG_SPOP_SBC_1

Location: 337:341

E3 ligase: SPOP

DEGRON score: 0.9832

ASA_SCORE: 69.92

COIL: 0.864

CONS_SCORE: 0.4011

DSS_SCORE: 0.4925

HELIX: 0.0862

FCONS_SCORE: 0.996

RIG_SCORE: 0.721

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E327K	TCGA-CQ-6218	HNSC	TCGA	AFTTS	DEG_SPOP_SBC_1	0.0556
p.E327K	DO14180	HNSC	ICGC	AFTTS	DEG_SPOP_SBC_1	0.0556
p.S336L	TCGA-DM-A1HA	COAD	TCGA	AFTTS	DEG_SPOP_SBC_1	0.3056
p.S336L	DO8754	COAD	ICGC	AFTTS	DEG_SPOP_SBC_1	0.3056
p.P332T	TCGA-EE-A181	SKCM	TCGA	AFTTS	DEG_SPOP_SBC_1	0.1944
p.P332T	DO37444	SKCM	ICGC	AFTTS	DEG_SPOP_SBC_1	0.1944
p.N333S	SIDM00652	Small Cell Lung Carcinoma	GDSC	AFTTS	DEG_SPOP_SBC_1	0.2222
p.N333S	ACH-000780	Lung Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	0.2222
p.N333S	NCI-H1105	lung	COSMIC	AFTTS	DEG_SPOP_SBC_1	0.2222
p.T331A	SIDM00315	Glioblastoma	GDSC	AFTTS	DEG_SPOP_SBC_1	0.1667
p.T331A	SIDM01469	Pancreatic Carcinoma	GDSC	AFTTS	DEG_SPOP_SBC_1	0.1667
p.T331A	ACH-000085	Pancreatic Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	0.1667
p.T331A	ACH-000570	Brain Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	0.1667
p.T331A	YKG-1	central_nervous_system	COSMIC	AFTTS	DEG_SPOP_SBC_1	0.1667
p.G335V	SIDM00552	Rhabdomyosarcoma	GDSC	AFTTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13017	Rho GTPase-activating protein 5	DEG_SPOP_SBC_1	1180:1184	AFTTS	SPOP	0.9837	More...
Q96PQ6	Zinc finger protein 317	DEG_SPOP_SBC_1	230:234	AFTTS	SPOP	0.6471	More...
Q9NY74	Ewing's tumor-associated antigen 1	DEG_SPOP_SBC_1	373:377	AFTTS	SPOP	0.6366	More...
Q9UMR3	T-box transcription factor TBX20	DEG_SPOP_SBC_1	337:341	AFTTS	SPOP	0.9832	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons