DegronMD

Uniprot ID: Q13017

Source protein: Rho GTPase-activating protein 5

Source gene: ARHGAP5

Class: DEG_SPOP_SBC_1

Location: 1180:1184

E3 ligase: SPOP

DEGRON score: 0.9837

ASA_SCORE: 78.66

COIL: 0.7032

CONS_SCORE: 0.3287

DSS_SCORE: 0.55

HELIX: 0.264

FCONS_SCORE: 0.9757

RIG_SCORE: 0.7061

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1182L	NCI-H1105	lung	COSMIC	AFTTS	DEG_SPOP_SBC_1	0.7582
p.P1182L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AFTTS	DEG_SPOP_SBC_1	0.7582
p.L1184P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AFTTS	DEG_SPOP_SBC_1	0.7582
p.S1176I	SIDM00120	Prostate Carcinoma	GDSC	AFTTS	DEG_SPOP_SBC_1	0.6667
p.S1176I	ACH-000979	Prostate Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	0.6667
p.S1176I	DU-145	prostate	COSMIC	AFTTS	DEG_SPOP_SBC_1	0.6667
p.V1176L	DU-145	prostate	COSMIC	AFTTS	DEG_SPOP_SBC_1	0.6667
p.E1179K	TCGA-AP-A1DK	UCEC	TCGA	AFTTS	DEG_SPOP_SBC_1	0.3056
p.E1179K	DO42033	UCEC	ICGC	AFTTS	DEG_SPOP_SBC_1	0.3056
p.D1177N	TCGA-AD-6899	COAD	TCGA	AFTTS	DEG_SPOP_SBC_1	0.25
p.D1177N	DO8818	COAD	ICGC	AFTTS	DEG_SPOP_SBC_1	0.25
p.R1188I	TCGA-B5-A11E	UCEC	TCGA	AFTTS	DEG_SPOP_SBC_1	0.2222
p.R1188I	DO41644	UCEC	ICGC	AFTTS	DEG_SPOP_SBC_1	0.2222
p.R1191K	TCGA-DA-A95Z	SKCM	TCGA	AFTTS	DEG_SPOP_SBC_1	0.1389
p.R1191K	DO222427	BTCA	ICGC	AFTTS	DEG_SPOP_SBC_1	0.1389
p.R1191K	DO219481	SKCM	ICGC	AFTTS	DEG_SPOP_SBC_1	0.1389
p.H1192P	TCGA-17-Z026	LUAD	TCGA	AFTTS	DEG_SPOP_SBC_1	0.1111
p.I1172T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AFTTS	DEG_SPOP_SBC_1	0.1111
p.R1193C	TCGA-BS-A0UF	UCEC	TCGA	AFTTS	DEG_SPOP_SBC_1	0.0833
p.R1193C	DO41488	UCEC	ICGC	AFTTS	DEG_SPOP_SBC_1	0.0833
p.G1194E	TCGA-CV-7568	HNSC	TCGA	AFTTS	DEG_SPOP_SBC_1	0.0556
p.G1194E	DO14160	HNSC	ICGC	AFTTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 22 of 22 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NY74	Ewing's tumor-associated antigen 1	DEG_SPOP_SBC_1	373:377	AFTTS	SPOP	0.6366	More...
Q13017	Rho GTPase-activating protein 5	DEG_SPOP_SBC_1	1180:1184	AFTTS	SPOP	0.9837	More...
Q9UMR3	T-box transcription factor TBX20	DEG_SPOP_SBC_1	337:341	AFTTS	SPOP	0.9832	More...
Q96PQ6	Zinc finger protein 317	DEG_SPOP_SBC_1	230:234	AFTTS	SPOP	0.6471	More...

Showing 1 to 4 of 4 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons