DegronMD

Uniprot ID: Q96PQ6

Source protein: Zinc finger protein 317

Source gene: ZNF317

Class: DEG_SPOP_SBC_1

Location: 230:234

E3 ligase: SPOP

DEGRON score: 0.6471

ASA_SCORE: 60.1

COIL: 0.6424

CONS_SCORE: 0.7462

DSS_SCORE: 0.335

HELIX: 0.0818

FCONS_SCORE: 1.012

RIG_SCORE: 0.7611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H244Y	TCGA-W3-AA1R	SKCM	TCGA	AFTTS	DEG_SPOP_SBC_1	0.0556
p.R238I	DO222762	COCA	ICGC	AFTTS	DEG_SPOP_SBC_1	0.2222
p.D229Y	DO228985	LICA	ICGC	AFTTS	DEG_SPOP_SBC_1	0.3056
p.G224W	DO23723	LUAD	ICGC	AFTTS	DEG_SPOP_SBC_1	0.1667
p.G224R	DO45485	LUSC	ICGC	AFTTS	DEG_SPOP_SBC_1	0.1667
p.P230L	DO229453	SKCA	ICGC	AFTTS	DEG_SPOP_SBC_1	0.7582
p.A226V	DO37471	SKCM	ICGC	AFTTS	DEG_SPOP_SBC_1	0.2222
p.L241P	DO41056	UCEC	ICGC	AFTTS	DEG_SPOP_SBC_1	0.1389
p.A237T	DO42256	UCEC	ICGC	AFTTS	DEG_SPOP_SBC_1	0.25
p.R239Q	SIDM01259	B-Lymphoblastic Leukemia	GDSC	AFTTS	DEG_SPOP_SBC_1	0.1944
p.R239Q	ACH-001669	Leukemia	CCLE	AFTTS	DEG_SPOP_SBC_1	0.1944
p.R239Q	ACH-002238	Leukemia	CCLE	AFTTS	DEG_SPOP_SBC_1	0.1944
p.A235T	SIDM00090	Ovarian Carcinoma	GDSC	AFTTS	DEG_SPOP_SBC_1	0.3056
p.A235T	ACH-000696	Ovarian Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	0.3056
p.A235T	OVCAR-8	ovary	COSMIC	AFTTS	DEG_SPOP_SBC_1	0.3056
p.S234T	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	AFTTS	DEG_SPOP_SBC_1	0.6005
p.S234T	ACH-000694	Esophageal Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	0.6005
p.S234T	TE-9	oesophagus	COSMIC	AFTTS	DEG_SPOP_SBC_1	0.6005
p.A235V	SIDM01577	Plasma Cell Myeloma	GDSC	AFTTS	DEG_SPOP_SBC_1	0.3056
p.A235V	ACH-000889	Myeloma	CCLE	AFTTS	DEG_SPOP_SBC_1	0.3056
p.A230G	SIDM01772	Mesothelioma	GDSC	AFTTS	DEG_SPOP_SBC_1	0.754
p.A230G	ACH-000531	Non-Cancerous	CCLE	AFTTS	DEG_SPOP_SBC_1	0.754
p.R238G	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	AFTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13017	Rho GTPase-activating protein 5	DEG_SPOP_SBC_1	1180:1184	AFTTS	SPOP	0.9837	More...
Q96PQ6	Zinc finger protein 317	DEG_SPOP_SBC_1	230:234	AFTTS	SPOP	0.6471	More...
Q9NY74	Ewing's tumor-associated antigen 1	DEG_SPOP_SBC_1	373:377	AFTTS	SPOP	0.6366	More...
Q9UMR3	T-box transcription factor TBX20	DEG_SPOP_SBC_1	337:341	AFTTS	SPOP	0.9832	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons