DegronMD - Q96PQ6(ZNF317)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H244Y	TCGA-W3-AA1R	SKCM	TCGA	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.0556
p.R238I	DO222762	COCA	ICGC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.2222
p.D229Y	DO228985	LICA	ICGC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.3056
p.G224W	DO23723	LUAD	ICGC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.1667
p.G224R	DO45485	LUSC	ICGC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.1667
p.P230L	DO229453	SKCA	ICGC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation altering degron motif	0.7582
p.A226V	DO37471	SKCM	ICGC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.2222
p.L241P	DO41056	UCEC	ICGC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.1389
p.A237T	DO42256	UCEC	ICGC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.25
p.R239Q	SIDM01259	B-Lymphoblastic Leukemia	GDSC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.1944
p.R239Q	ACH-001669	Leukemia	CCLE	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.1944
p.R239Q	ACH-002238	Leukemia	CCLE	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.1944
p.A235T	SIDM00090	Ovarian Carcinoma	GDSC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.3056
p.A235T	ACH-000696	Ovarian Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.3056
p.A235T	OVCAR-8	ovary	COSMIC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.3056
p.S234T	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation altering degron motif	0.6005
p.S234T	ACH-000694	Esophageal Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation altering degron motif	0.6005
p.S234T	TE-9	oesophagus	COSMIC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation altering degron motif	0.6005
p.A235V	SIDM01577	Plasma Cell Myeloma	GDSC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.3056
p.A235V	ACH-000889	Myeloma	CCLE	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.3056
p.A230G	SIDM01772	Mesothelioma	GDSC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation altering degron motif	0.754
p.A230G	ACH-000531	Non-Cancerous	CCLE	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation altering degron motif	0.754
p.R238G	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	AFTTS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.2222

Kaplan plot for ZNF317 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF317

UniProt ID: Q96PQ6

Entrez ID: 57693

Protein name: Zinc finger protein 317

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF317 in