DegronMD

Uniprot ID: Q9NY74

Source protein: Ewing's tumor-associated antigen 1

Source gene: ETAA1

Class: DEG_SPOP_SBC_1

Location: 373:377

E3 ligase: SPOP

DEGRON score: 0.6366

ASA_SCORE: 68.62

COIL: 0.7576

CONS_SCORE: 0.5475

DSS_SCORE: 0.3942

HELIX: 0.184

FCONS_SCORE: 0.9323

RIG_SCORE: 0.8198

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D378V	TCGA-AG-A002	READ	TCGA	AFTTS	DEG_SPOP_SBC_1	0.3056
p.K369N	DO229018	LICA	ICGC	AFTTS	DEG_SPOP_SBC_1	0.3333
p.S377I	ACH-001061	Colon/Colorectal Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13017	Rho GTPase-activating protein 5	DEG_SPOP_SBC_1	1180:1184	AFTTS	SPOP	0.9837	More...
Q96PQ6	Zinc finger protein 317	DEG_SPOP_SBC_1	230:234	AFTTS	SPOP	0.6471	More...
Q9NY74	Ewing's tumor-associated antigen 1	DEG_SPOP_SBC_1	373:377	AFTTS	SPOP	0.6366	More...
Q9UMR3	T-box transcription factor TBX20	DEG_SPOP_SBC_1	337:341	AFTTS	SPOP	0.9832	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons