DegronMD - Q13017(ARHGAP5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H1192P	TCGA-17-Z026	LUAD	TCGA	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.1111
p.D1177N	TCGA-AD-6899	COAD	TCGA	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.25
p.D1177N	DO8818	COAD	ICGC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.25
p.E1179K	TCGA-AP-A1DK	UCEC	TCGA	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.3056
p.E1179K	DO42033	UCEC	ICGC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.3056
p.R1188I	TCGA-B5-A11E	UCEC	TCGA	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.2222
p.R1188I	DO41644	UCEC	ICGC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.2222
p.R1193C	TCGA-BS-A0UF	UCEC	TCGA	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.0833
p.R1193C	DO41488	UCEC	ICGC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.0833
p.G1194E	TCGA-CV-7568	HNSC	TCGA	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.0556
p.G1194E	DO14160	HNSC	ICGC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.0556
p.P989S	TCGA-CV-A461	HNSC	TCGA	PPPY	ITCH	988:991	Mutation altering degron motif	0.6752
p.P989S	DO49058	HNSC	ICGC	PPPY	ITCH	988:991	Mutation altering degron motif	0.6752
p.R1191K	TCGA-DA-A95Z	SKCM	TCGA	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.1389
p.R1191K	DO222427	BTCA	ICGC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.1389
p.R1191K	DO219481	SKCM	ICGC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.1389
p.I994F	TCGA-DV-5568	KIRC	TCGA	PPPY	ITCH	988:991	Mutation rewiring degron network	0.25
p.I994F	DO18402	KIRC	ICGC	PPPY	ITCH	988:991	Mutation rewiring degron network	0.25
p.A987V	TCGA-FG-A4MT	LGG	TCGA	PPPY	ITCH	988:991	Mutation rewiring degron network	0.3056
p.A987V	DO44559	LGG	ICGC	PPPY	ITCH	988:991	Mutation rewiring degron network	0.3056
p.S992I	DO229035	LICA	ICGC	PPPY	ITCH	988:991	Mutation rewiring degron network	0.3056
p.Y991C	DO44696	LICA	ICGC	PPPY	ITCH	988:991	Mutation altering degron motif	0.7087
p.S1176I	SIDM00120	Prostate Carcinoma	GDSC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation blocking phosphorylation signal	0.6667
p.S1176I	ACH-000979	Prostate Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation blocking phosphorylation signal	0.6667
p.S1176I	DU-145	prostate	COSMIC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation blocking phosphorylation signal	0.6667
p.P1182L	NCI-H1105	lung	COSMIC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation altering degron motif	0.7582
p.P1182L	Daudi	haematopoietic and lymphoid tissue	COSMIC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation altering degron motif	0.7582
p.V1176L	DU-145	prostate	COSMIC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation blocking phosphorylation signal	0.6667
p.L1184P	Daudi	haematopoietic and lymphoid tissue	COSMIC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation altering degron motif	0.7582
p.I1172T	Daudi	haematopoietic and lymphoid tissue	COSMIC	AFTTS	DEG_SPOP_SBC_1	1180:1184	Mutation rewiring degron network	0.1111

Kaplan plot for ARHGAP5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP5

UniProt ID: Q13017

Entrez ID: 394

Protein name: Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP5 in