DegronMD - Q9NY74(ETAA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P11R	TCGA-23-2645	OV	TCGA	PKKTPHKT	DEG_SCF_FBW7_1	13:20	Mutation rewiring degron network	0.2778
p.P11R	DO30890	OV	ICGC	PKKTPHKT	DEG_SCF_FBW7_1	13:20	Mutation rewiring degron network	0.2778
p.P391S	TCGA-2G-AAKH	TGCT	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.2222
p.P771R	TCGA-49-4507	LUAD	TCGA	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.7512
p.P771R	DO25727	LUAD	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.7512
p.D378V	TCGA-AG-A002	READ	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.3056
p.D378V	TCGA-AG-A002	READ	TCGA	AFTTS	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.3056
p.D381N	TCGA-BT-A2LB	BLCA	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5821
p.D381N	DO44098	BLCA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5821
p.P391R	TCGA-DD-AACA	LIHC	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.2222
p.P391R	DO52196	LIHC	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.2222
p.D382E	TCGA-DX-AB2W	SARC	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5647
p.D382E	DO220095	SARC	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5647
p.S359F	TCGA-EE-A29V	SKCM	TCGA	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation blocking phosphorylation signal	0.6111
p.S359F	DO38006	SKCM	ICGC	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation blocking phosphorylation signal	0.6111
p.L386V	TCGA-F5-6814	READ	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5654
p.L386V	TCGA-VQ-A94R	STAD	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5654
p.L386V	DO36556	READ	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5654
p.L386V	DO222372	STAD	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5654
p.R341Q	TCGA-FI-A2D5	UCEC	TCGA	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation rewiring degron network	0.1667
p.R341Q	DO41331	UCEC	ICGC	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation rewiring degron network	0.1667
p.P17R	DO6988	CLLE	ICGC	PKKTPHKT	DEG_SCF_FBW7_1	13:20	Mutation altering degron motif	0.7512
p.S389N	DO227999	COCA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.2778
p.S389N	DO229010	COCA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.2778
p.S389N	DO229003	COCA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.2778
p.S389N	DO229005	COCA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.2778
p.S389N	DO230550	LUSC	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.2778
p.P771S	DO227999	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.6752
p.P771S	DO229010	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.6752
p.P771S	DO229003	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.6752
p.P771S	DO229005	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.6752
p.P771S	DO230550	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.6752
p.G27V	DO223014	ESCA	ICGC	PKKTPHKT	DEG_SCF_FBW7_1	13:20	Mutation rewiring degron network	0.1389
p.C356Y	DO51005	LAML	ICGC	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation rewiring degron network	0.25
p.C356Y	SIDM01307	Colorectal Carcinoma	GDSC	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation rewiring degron network	0.25
p.V769G	DO228844	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.2778
p.V347L	DO228986	LICA	ICGC	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation altering degron motif	0.5654
p.K369N	DO229018	LICA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation substituting flanking lysine	0.1667
p.K369N	DO229018	LICA	ICGC	AFTTS	DEG_SPOP_SBC_1	373:377	Mutation substituting flanking lysine	0.3333
p.E24D	DO229032	LICA	ICGC	PKKTPHKT	DEG_SCF_FBW7_1	13:20	Mutation rewiring degron network	0.2222
p.R5M	DO229006	LICA	ICGC	PKKTPHKT	DEG_SCF_FBW7_1	13:20	Mutation rewiring degron network	0.1111
p.M783R	DO50685	ORCA	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.1111
p.N396S	SIDM00570	Gastric Carcinoma	GDSC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.0833
p.N396S	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.0833
p.N396S	NUGC-4	stomach	COSMIC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.0833
p.N396S	EMC-BAC-1	lung	COSMIC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.0833
p.R341G	SIDM00845	Burkitt's Lymphoma	GDSC	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation rewiring degron network	0.1667
p.R341G	SIDM01117	Small Cell Lung Carcinoma	GDSC	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation rewiring degron network	0.1667
p.R341G	SIDM00863	Burkitt's Lymphoma	GDSC	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation rewiring degron network	0.1667
p.N764H	SIDM01196	Hepatocellular Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.1389
p.N764H	SNU-475	liver	COSMIC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.1389
p.L343F	SIDM00516	Melanoma	GDSC	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation rewiring degron network	0.2222
p.L343F	ACH-002166	Skin Cancer	CCLE	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation rewiring degron network	0.2222
p.L343F	MZ7-mel	skin	COSMIC	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation rewiring degron network	0.2222
p.S389C	SIDM00148	Breast Carcinoma	GDSC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.2778
p.S389C	ACH-000019	Breast Cancer	CCLE	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.2778
p.S389C	MCF7	breast	COSMIC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation rewiring degron network	0.2778
p.S774L	SIDM01694	B-Lymphoblastic Leukemia	GDSC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.7667
p.S774L	ACH-000728	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.7667
p.S377I	ACH-001061	Colon/Colorectal Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	373:377	Mutation altering degron motif	0.7341
p.P13Q	ACH-001577	Leukemia	CCLE	PKKTPHKT	DEG_SCF_FBW7_1	13:20	Mutation altering degron motif	0.7035

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ETAA1

UniProt ID: Q9NY74

Entrez ID: 54465

Protein name: Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ETAA1 in