DegronMD - Q9NY74(ETAA1)

FUNCTION: Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723720, PubMed:27723717). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723720, PubMed:27723717). Probably only regulates a subset of ATR targets (PubMed:27723720, PubMed:27723717). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720}.

GO - Biological processes (BP): cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of DNA damage checkpoint [GO:2000001]; replication fork processing [GO:0031297]

GO - Molecular function (MF): protein serine/threonine kinase activator activity [GO:0043539]

GO - Cellular component (CC): cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S774L	SIDM01694	B-Lymphoblastic Leukemia	GDSC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.7667
p.S774L	ACH-000728	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.7667
p.P771R	TCGA-49-4507	LUAD	TCGA	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.7512
p.P771R	DO25727	LUAD	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.7512
p.P17R	DO6988	CLLE	ICGC	PKKTPHKT	DEG_SCF_FBW7_1	13:20	Mutation altering degron motif	0.7512
p.S377I	ACH-001061	Colon/Colorectal Cancer	CCLE	AFTTS	DEG_SPOP_SBC_1	373:377	Mutation altering degron motif	0.7341
p.P13Q	ACH-001577	Leukemia	CCLE	PKKTPHKT	DEG_SCF_FBW7_1	13:20	Mutation altering degron motif	0.7035
p.P771S	DO227999	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.6752
p.P771S	DO229010	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.6752
p.P771S	DO229003	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.6752
p.P771S	DO229005	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.6752
p.P771S	DO230550	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.6752
p.S359F	TCGA-EE-A29V	SKCM	TCGA	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation blocking phosphorylation signal	0.6111
p.S359F	DO38006	SKCM	ICGC	VDTPIMT	DEG_SCF_FBW7_1	347:353	Mutation blocking phosphorylation signal	0.6111
p.D381N	TCGA-BT-A2LB	BLCA	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5821
p.D381N	DO44098	BLCA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5821
p.L386V	TCGA-F5-6814	READ	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5654
p.L386V	TCGA-VQ-A94R	STAD	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5654
p.L386V	DO36556	READ	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5654
p.L386V	DO222372	STAD	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	379:387	Mutation altering degron motif	0.5654

Showing 1 to 20 of 61 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ETAA1

UniProt ID: Q9NY74

Entrez ID: 54465

Protein name: Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ETAA1 in