DegronMD

Uniprot ID: Q9NY74

Source protein: Ewing's tumor-associated antigen 1

Source gene: ETAA1

Class: DEG_SCF_FBW7_1

Location: 347:353

E3 ligase: FBXW7

DEGRON score: 0.9723

ASA_SCORE: 87.0429

COIL: 0.868

CONS_SCORE: 0.4007

DSS_SCORE: 0.3813

HELIX: 0.0823

FCONS_SCORE: 0.9038

RIG_SCORE: 0.7632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S359F	TCGA-EE-A29V	SKCM	TCGA	VDTPIMT	DEG_SCF_FBW7_1	0.6111
p.S359F	DO38006	SKCM	ICGC	VDTPIMT	DEG_SCF_FBW7_1	0.6111
p.R341Q	TCGA-FI-A2D5	UCEC	TCGA	VDTPIMT	DEG_SCF_FBW7_1	0.1667
p.R341Q	DO41331	UCEC	ICGC	VDTPIMT	DEG_SCF_FBW7_1	0.1667
p.C356Y	DO51005	LAML	ICGC	VDTPIMT	DEG_SCF_FBW7_1	0.25
p.C356Y	SIDM01307	Colorectal Carcinoma	GDSC	VDTPIMT	DEG_SCF_FBW7_1	0.25
p.V347L	DO228986	LICA	ICGC	VDTPIMT	DEG_SCF_FBW7_1	0.5654
p.R341G	SIDM00845	Burkitt's Lymphoma	GDSC	VDTPIMT	DEG_SCF_FBW7_1	0.1667
p.R341G	SIDM01117	Small Cell Lung Carcinoma	GDSC	VDTPIMT	DEG_SCF_FBW7_1	0.1667
p.R341G	SIDM00863	Burkitt's Lymphoma	GDSC	VDTPIMT	DEG_SCF_FBW7_1	0.1667
p.L343F	SIDM00516	Melanoma	GDSC	VDTPIMT	DEG_SCF_FBW7_1	0.2222
p.L343F	ACH-002166	Skin Cancer	CCLE	VDTPIMT	DEG_SCF_FBW7_1	0.2222
p.L343F	MZ7-mel	skin	COSMIC	VDTPIMT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NY74	Ewing's tumor-associated antigen 1	DEG_SCF_FBW7_1	347:353	VDTPIMT	FBXW7	0.9723	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons