DegronMD

Uniprot ID: Q9NY74

Source protein: Ewing's tumor-associated antigen 1

Source gene: ETAA1

Class: DEG_MDM2_SWIB_1

Location: 379:387

E3 ligase: MDM2

DEGRON score: 0.8154

ASA_SCORE: 64.8778

COIL: 0.5524

CONS_SCORE: 0.7853

DSS_SCORE: 0.4239

HELIX: 0.4154

FCONS_SCORE: 1.4511

RIG_SCORE: 0.8291

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P391S	TCGA-2G-AAKH	TGCT	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	0.2222
p.D378V	TCGA-AG-A002	READ	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	0.3056
p.D381N	TCGA-BT-A2LB	BLCA	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	0.5821
p.D381N	DO44098	BLCA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	0.5821
p.P391R	TCGA-DD-AACA	LIHC	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	0.2222
p.P391R	DO52196	LIHC	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	0.2222
p.D382E	TCGA-DX-AB2W	SARC	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	0.5647
p.D382E	DO220095	SARC	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	0.5647
p.L386V	TCGA-F5-6814	READ	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	0.5654
p.L386V	TCGA-VQ-A94R	STAD	TCGA	FEDDWENLL	DEG_MDM2_SWIB_1	0.5654
p.L386V	DO36556	READ	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	0.5654
p.L386V	DO222372	STAD	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	0.5654
p.S389N	DO227999	COCA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	0.2778
p.S389N	DO229010	COCA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	0.2778
p.S389N	DO229003	COCA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	0.2778
p.S389N	DO229005	COCA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	0.2778
p.S389N	DO230550	LUSC	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	0.2778
p.K369N	DO229018	LICA	ICGC	FEDDWENLL	DEG_MDM2_SWIB_1	0.1667
p.N396S	SIDM00570	Gastric Carcinoma	GDSC	FEDDWENLL	DEG_MDM2_SWIB_1	0.0833
p.N396S	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	FEDDWENLL	DEG_MDM2_SWIB_1	0.0833
p.N396S	NUGC-4	stomach	COSMIC	FEDDWENLL	DEG_MDM2_SWIB_1	0.0833
p.N396S	EMC-BAC-1	lung	COSMIC	FEDDWENLL	DEG_MDM2_SWIB_1	0.0833
p.S389C	SIDM00148	Breast Carcinoma	GDSC	FEDDWENLL	DEG_MDM2_SWIB_1	0.2778
p.S389C	ACH-000019	Breast Cancer	CCLE	FEDDWENLL	DEG_MDM2_SWIB_1	0.2778
p.S389C	MCF7	breast	COSMIC	FEDDWENLL	DEG_MDM2_SWIB_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NY74	Ewing's tumor-associated antigen 1	DEG_MDM2_SWIB_1	379:387	FEDDWENLL	MDM2	0.8154	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FEDDWENLL

Degron related mutations and impact score

Drug responses associated with ETAA1 mutations

All proteins holding degron of FEDDWENLL