DegronMD - Q3MII6(TBC1D25)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N516S	TCGA-06-5416	GBM	TCGA	RRDPLVQLP	DEG_APCC_DBOX_1	520:528	Mutation rewiring degron network	0.2222
p.P528L	TCGA-90-A4ED	LUSC	TCGA	RRDPLVQLP	DEG_APCC_DBOX_1	520:528	Mutation altering degron motif	0.6471
p.L513R	TCGA-A6-3809	COAD	TCGA	RRDPLVQLP	DEG_APCC_DBOX_1	520:528	Mutation rewiring degron network	0.1389
p.P566Q	TCGA-A8-A09Z	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	560:564	Mutation rewiring degron network	0.2778
p.S519F	TCGA-AP-A1DV	UCEC	TCGA	RRDPLVQLP	DEG_APCC_DBOX_1	520:528	Mutation rewiring degron network	0.3056
p.S561T	TCGA-AX-A2H4	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	560:564	Mutation altering degron motif	0.6005
p.S553C	TCGA-DU-7006	LGG	TCGA	PSSSS	DEG_SPOP_SBC_1	560:564	Mutation rewiring degron network	0.1389
p.P573L	TCGA-FW-A3R5	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	560:564	Mutation rewiring degron network	0.0833
p.S536Y	TCGA-L9-A444	LUAD	TCGA	RRDPLVQLP	DEG_APCC_DBOX_1	520:528	Mutation rewiring degron network	0.1111
p.I534T	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRDPLVQLP	DEG_APCC_DBOX_1	520:528	Mutation rewiring degron network	0.1667
p.I534T	ACH-002062	Lymphoma	CCLE	RRDPLVQLP	DEG_APCC_DBOX_1	520:528	Mutation rewiring degron network	0.1667
p.I534T	SLVL	haematopoietic and lymphoid tissue	COSMIC	RRDPLVQLP	DEG_APCC_DBOX_1	520:528	Mutation rewiring degron network	0.1667

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons